Publications by authors named "Jyotika Dixit"
Mol Cell Biol
November 2024
Article Synopsis
- The deregulation of a specific transcription factor is key in the development of T cell acute lymphoblastic leukemia (T-ALL), mainly due to mutations in exon 4 that disrupt its DNA-binding ability.
- The study highlights the role of Activation-induced cytidine deaminase (AID) in mutagenesis, showing that AID is present in T-ALL cells and creates distinct mutation patterns by binding to fragile regions in the DNA.
- AID's binding leads to the formation of complex DNA structures that can cause errors during replication, ultimately resulting in harmful mutations that impair the transcription factor's function and contribute to the onset of T-ALL.
