Aerosol drug therapy in critically ill patients (Aero-in-ICU study): A multicentre prospective observational cohort study.

Background: In recent years, a significant understanding of delivering optimal aerosol therapy and the availability of various drugs and devices have led to an increase in its use in clinical practice. There are only a few studies available regarding their use in critically ill patients from a few parts of the world. We aimed to study the practice pattern of aerosol therapy in critically ill patients from Indian intensive care units (ICUs).

Prone ventilation in H1N1 virus-associated severe acute respiratory distress syndrome: A case series.

Background: Management of H1N1 viral infection-associated acute respiratory distress syndrome (ARDS) has primarily been focused on lung protective ventilation strategies, despite that mortality remains high (up to 45%). Other measures to improve survival are prone position ventilation (PPV) and extracorporeal membrane oxygenation. There is scarcity of literature on the use of prone ventilation in H1N1-associated ARDS patients.

Acute respiratory failure in scrub typhus patients.

Respiratory failure is a serious complication of scrub typhus. In this prospective study, all patients with a diagnosis of scrub typhus were included from a single center Intensive Care Unit (ICU). Demographic, clinical characteristics, laboratory, and imaging parameters of these patients at the time of ICU admission were compared.

Should we do early and frequent charcoal hemoperfusion in phenytoin toxicity?

Phenytoin toxicity or adverse drug reaction is common due to its narrow therapeutic window. Mild and moderate toxicity require supportive care and enteral activated charcoal. In severe toxicity, charcoal hemoperfusion (CHP) have been shown to decrease serum phenytoin half-life and early recovery.

Deep-vein thrombosis and septic pulmonary emboli in methicillin-sensitive Staphylococcus aureus infection.

Deep-vein thrombosis (DVT) in children is most often secondary to a predisposing cause. DVT and septic pulmonary emboli in staphylococcal sepsis has been described most often with methicillin-resistant Staphylococcus aureus. The clinical features of four previously healthy children with community-acquired, methicillin-sensitive Staphylococcus aureus sepsis associated with DVT are described.