Publications by authors named "Jyoti B Sharma"
Article Synopsis
- Cryptococcosis is a severe fungal infection primarily affecting those with HIV, often leading to cryptococcal meningitis, which is a major cause of death in these patients.
- A 50-year-old man with newly diagnosed HIV-1 presented with symptoms of altered mental status, low-grade fever, and weight loss, and was treated with a combination of antifungal therapies including Liposomal Amphotericin B.
- The treatment was successful, and the patient showed significant improvement after 6 months, suggesting that this antifungal regimen may be effective for managing cryptococcal infections in HIV-infected individuals.
Tuberculous pachymeningitis is a rare disease that should be suspected in patients with chronic headaches, focal neurological signs, and magnetic resonance imaging (MRI) findings of dural thickening. We report the case of a 62-year-old male who presented with chronic headaches for over a year, progressive right-sided vision and hearing loss for six months, and progressive dysphagia for a month. On investigation, MRI showed dural thickening, cerebrospinal fluid showed lymphocytic pleocytosis with high protein and normal glucose levels, and biopsy of the dural matter showed necrotizing granulomas with Langhans giant cells.
View Article and Find Full Text PDFAim: Accurate causality assessment (CA) of adverse events (AEs) is important in clinical research and routine clinical practice. The Naranjo scale (NS) used for CA lacks specificity, leading to a high rate of false positive causal associations. NS is a simple scale for CA; however, its limitations have reduced its popularity in favour of other scales.
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