Synthesis of chalcone incorporated quinazoline derivatives as anticancer agents.

A series of ten novel chalcone incorporated quinazoline derivatives (-) were designed and synthesized. All the synthesized compounds were evaluated for their anticancer activities against four human cancer cell lines (A549, HT-29, MCF-7 and A375). Among them, four compounds, , , and showed more potent anticancer activity than the control drug, Combretastatin - A4.