Unlocking the potential: integrating phytoconstituents and nanotechnology in skin cancer therapy - A comprehensive review.

Skin carcinoma, which includes basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma, is influenced by various factors such as genetic predisposition, chemical exposures, immune system imbalances, and ultraviolet (UV) radiation. This review delves into the mechanisms behind the development of these cancers, exploring the therapeutic potential of microbial, plant derived compounds and nanoparticles in advancing skin cancer treatments. Special attention is given to the cytotoxic effects of anti-neoplastic agents from microbial sources on different cancer cell lines, particularly melanoma.

Inflammatory signaling pathways in Alzheimer's disease: Mechanistic insights and possible therapeutic interventions.

The complex pathophysiology of Alzheimer's disease (AD) poses challenges for the development of therapies. Recently, neuroinflammation has been identified as a key pathogenic mechanism underlying AD, while inflammation has emerged as a possible target for the management and prevention of AD. Several prior studies have demonstrated that medications modulating neuroinflammation might lessen AD symptoms, mostly by controlling neuroinflammatory signaling pathways such as the NF-κB, MAPK, NLRP3, etc, and their respective signaling cascade.

Inhibitors of the mTOR signaling pathway can play an important role in breast cancer immunopathogenesis.

This study explores the critical role of inhibitors targeting the mammalian target of rapamycin (mTOR) signaling pathway in breast cancer research and treatment. The mTOR pathway, a central regulator of cellular processes, has been identified as a crucial factor in the development and progression of breast cancer. The essay explains the complex molecular mechanisms through which mTOR inhibitors, such as rapamycin and its analogs, exert their anticancer effects.

Graphene oxide nanoribbons conjugated with 1, 2-distearoyl-sn-glycero-3 phosphoethanolamine-poly (ethylene glycol)-transferrin enhanced targeted delivery and cytotoxicity of raloxifene against breast cancer.

The clinical utility of raloxifene (RLX), a selective estrogen receptor modulator (SERM), has been compromised by severe side effects and unfavorable drug properties. To address these, a transferrin (Tf) conjugated graphene oxide nanoribbon (GONR) platform was tried for RLX. The stability of GONRs in biological media was improved by surface modification with 1, 2-Distearoyl-sn-glycero-3 phosphoethanolamine-Poly (ethylene glycol) (DSPE-PEG).

Emerging roles of long noncoding RNA H19 in human lung cancer.

Lung cancer holds the position of being the primary cause of cancer-related fatalities on a global scale. Furthermore, it exhibits the highest mortality rate among all types of cancer. The survival rate within a span of 5 years is less than 20%, primarily due to the fact that the disease is often diagnosed at an advanced stage, resulting in less effective treatment options compared to earlier stages.

Highlighting the role of long non-coding RNA (LncRNA) in multiple myeloma (MM) pathogenesis and response to therapy.

Transcripts longer than 200 nucleotides that are not translated into proteins are known as long non-coding RNAs, or lncRNAs. Now, they are becoming more significant as important regulators of gene expression, and as a result, of many biological processes in both healthy and pathological circumstances, such as blood malignancies. Through controlling alternative splicing, transcription, and translation at the post-transcriptional level, lncRNAs have an impact on the expression of genes.

Study on the impact of sensitization on materiovigilance programme among pharmacy and dental postgraduate students.

Background: Medical devices play a crucial role in patient care but entail inherent risks, necessitating the presence of materiovigilance to monitor and prevent medical device adverse events (MDAEs). The primary objective of our study is to evaluate the impact of an awareness and sensitization program regarding medical devices among participants.

Methods: A self-administered, validated knowledge, attitude, and practice (KAP) questionnaire consisting of 15 questions was distributed to study participants, and their responses were collected.

Safe injection, infusion and medication-vial practices at a tertiary care centre: a quality improvement initiative.

Introduction: There is a risk of transmission of viruses and microbial pathogens during routine health care procedures due to improper injection, infusion, and medication-vial practices. Unsafe practices lead to outbreaks of infection resulting in unacceptable and devastating events in patients. The present study was undertaken to assess the compliance of nurses with safe injection and infusion practices in our hospital and to identify staff education requirements in relation to the safe-injection and infusion practices policy.

Characterization of phytoplankton functional groups in a tropical shellfish harvesting estuary (Ashtamudi) and adjacent nearshore waters (southwest coast of India).

A pioneering study on phytoplankton marker pigments, by adopting the HPLC-CHEMTAX analytical approach, was carried out in one of the major shellfish harvesting estuaries (Ashtamudi estuary-AE) on the southwest coast of India and also its adjacent nearshore waters (< 20 m depth) to study the dynamics of phytoplankton functional groups (PFGs). The AE, in general, appeared to be warm (> 29 °C) during the non-monsoon seasons, along with the prevalence of higher salinity (> 25) and NH-N (> 5 µM) levels. However, during the summer monsoon (SM), the prevailing substantial river influx converted the AE into a low salinity (< 10) dominated system, provided with enhanced levels of NO-N (4.

Biowaste-Derived, Highly Efficient, Reusable Carbon Nanospheres for Speedy Removal of Organic Dyes from Aqueous Solutions.

The current work explores the adsorptive efficiency of carbon nanospheres (CNSs) derived from oil palm leaves (OPL) that are a source of biowaste. CNSs were synthesized at 400, 600, 800 and 1000 °C, and those obtained at 1000 °C demonstrated maximum removal efficiency of ~91% for malachite green (MG). Physicochemical and microscopic characteristics were analysed by FESEM, TEM, FTIR, Raman, TGA and XPS studies.

Use of Valproate in Women: An Audit of Prescriptions to 10,001 Psychiatry, Neurology, and Neurosurgery Outpatients.

Gestational exposure to valproate is associated with an unacceptably high risk of major congenital malformations, neurodevelopmental disorders, and other adverse outcomes. Prescription of valproate to reproductive-age women is therefore strongly discouraged in many parts of the world. To our knowledge, there is no pharmacoepidemiologic study of the prescription of valproate to women in a developing country.

Implications of a conserved region of bluetongue virus protein VP2 in cross-neutralisation of bluetongue virus serotypes.

Bluetongue (BT) is a vector-borne disease of ruminants caused by Bluetongue virus (BTV). Twenty-nine different serotypes of BTV are currently reported throughout the world. The main objective of this study is the development of a subunit vaccine model that could potentially be adapted to provide broad spectrum protection against multiple BTV serotypes, which the conventional vaccines fail to address.

Photon-mediated charge exchange reactions between K atoms and Ca ions in a hybrid trap.

We present experimental evidence of charge exchange between laser-cooled potassium K atoms and calcium Ca ions in a hybrid atom-ion trap and give quantitative theoretical explanations for the observations. The K atoms and Ca ions are held in a magneto-optical (MOT) and a linear Paul trap, respectively. Fluorescence detection and high resolution time of flight mass spectra for both species are used to determine the remaining number of Ca ions, the increasing number of K ions, and K number density as functions of time.

Novel treatment of in-office tooth bleaching sensitivity: A randomized, placebo-controlled clinical study.

Objectives: Aim of this clinical trial was to investigate the effect of a calcium phosphate based desensitizer paste applied prior to in-office tooth whitening on bleaching sensitivity (BS).

Methods: This crossover study was designed as randomized double-blinded, placebo-controlled trial. The desensitizer paste Teethmate AP (TAP) contains tetracalcium phosphate and dicalcium phosphate anhydrous in glycerol and polyethylene glycol, whereas placebo (PLA) is a calcium phosphate free analog.

Photodissociation of Trapped Rb_{2}^{+}: Implications for Simultaneous Trapping of Atoms and Molecular Ions.

The direct photodissociation of trapped ^{85}Rb_{2}^{+} (rubidium) molecular ions by the cooling light for the ^{85}Rb magneto-optical trap (MOT) is studied, both experimentally and theoretically. Vibrationally excited Rb_{2}^{+} ions are created by photoionization of Rb_{2} molecules formed photoassociatively in the Rb MOT and are trapped in a modified spherical Paul trap. The decay rate of the trapped Rb_{2}^{+} ion signal in the presence of the MOT cooling light is measured and agreement with our calculated rates for molecular ion photodissociation is observed.

Correlation of Audio-Visual Reaction Time with Body Mass Index & Skin Fold Thickness Between Runners and Healthy Controls.

Audio-visual reaction time is essential for activities like driving and very important in sports persons. Reaction time of 31 National level runners was compared with 31 controls. Runners were subdivided into two groups, group A (>2 yrs & < 3 yrs of training) and group B (>3 yrs & < 10 yrs of training).

Use of smartphone apps by paediatric trainees.

Over 70% of the population owns a smartphone and there are now millions of apps available. This study looks at smartphone and app use among paediatric trainees, in particular whether they are accessing medical apps to help with clinical practice.

Difficult indirect carotid-cavernous fistulas--alternative techniques to gaining access for treatment.

Aims: Carotid-cavernous fistulas (CCFs) are abnormal communications between the carotid arterial system and the cavernous sinus that occur mainly in elderly. Occasionally, treatment of indirect CCFs with conventional endovascular approach through large veins or the inferior petrosal sinus may not be possible. In these cases, a direct surgical cut down on to the superior ophthalmic vein (SOV) is necessary.

Risk assessment of rooftop-collected rainwater for individual household and community use in central Kerala, India.

Water quality of rooftop-collected rainwater is an issue of increased interest particularly in developing countries where the collected water is used as a source of drinking water. Bacteriological and chemical parameters of 25 samples of rooftop-harvested rainwater stored in ferrocement tanks were analyzed in the study described in this article. Except for the pH and lower dissolved oxygen levels, all other physicochemical parameters were within World Health Organization guidelines.

Immune deficiencies in children: an overview.

Primary immune deficiencies (PIDs) are disorders of the immune system that result in increased susceptibility to infectious disease, autoimmunity and malignancy. They are challenging to paediatricians as they can present anytime from birth to adolescence with a wide variety of signs and symptoms. It is important to diagnose PIDs promptly, especially more severe forms to prevent significant morbidity and mortality.

Evaluation of single-tooth replacement by an immediate implant covered with connective tissue graft as a biologic barrier.

Background And Objectives: The aim of the present study was to evaluate the survival rate of Screw-Vent(®) immediate implants augmented with sub epithelial connective tissue graft for single-tooth replacement for 1 year.

Materials And Methods: Ten patients (five men and five women), with the mean age of 25.3 years, were consecutively treated on the out-patient basis by the placement of Screw-Vent(®) dental implants in to the fresh extraction sockets in association of augmentation with sub epithelial connective tissue graft harvested from the palate, supporting single crowns.

Immune deficiencies in children: an overview.

Primary immune deficiencies (PIDs) are disorders of the immune system that result in increased susceptibility to infectious disease, autoimmunity and malignancy. They are challenging to paediatricians as they can present anytime from birth to adolescence with a wide variety of signs and symptoms. It is important to diagnose PIDs promptly, especially more severe forms to prevent significant morbidity and mortality.

Depositional behaviour of C-org, N, P and K in the surface sediments of two shallow water bodies in a tropical coast, India.

The present paper deals with the distribution of sediment and sediment-bound nutrients in two important coastal lagoons of southern Kerala such as the Ashtamudi Estuarine Lagoon in the Kollam district and the Kadinamkulam Lagoon in the Thiruvananthapuram district. Among the two lagoons, the former is coast perpendicular, and the latter is coast parallel. An analysis of the textural characteristics reveals that, in both lagoons, the estuarine mouth and areas close to it are dominated by sand and sand-rich sediment species, indicating a high-energy depositional regime prevailing the region.