Fixed-Dose Recombinant Urate Oxidase in the Treatment of Paediatric Tumour Lysis Syndrome: A Regional Cancer Centre Experience.

Background: Tumor lysis syndrome (TLS) is an oncologic emergency commonly seen in children with hemato-lymphoid malignancies. Recombinant urate oxidase (RUO) is used in both the prophylaxis and treatment of TLS. However, in resource-constrained countries, its role is mostly limited to the treatment of established TLS and data regarding the use of RUO and its outcome is sparse.

Pearson syndrome: a rare inborn error of metabolism with bone marrow morphology providing a clue to diagnosis.

Pearson syndrome is a rare disorder of mitochondrial metabolism presenting in infancy with transfusion dependent refractory anaemia and multisystem involvement. We report a case of a 3-month-old infant presenting with anaemia requiring multiple transfusions. The presence of lactic acidosis, hyperglycaemia and cytoplasmic vacuoles in erythroid precursors on bone marrow aspiration study helped to suspect the diagnosis.

Glanzmann Thrombasthenia in Children: Experience From a Tertiary Care Center in Southern India.

Background: Glanzmann thrombasthenia (GT) is a globally rare inherited disorder of hemostasis.

Objectives: To describe the clinical profile of GT in a tertiary care center in Southern India.

Methods: A retrospective chart review of all children with GT was performed between January 2005 and August 2017 in the Department of Paediatrics.

Multidetector Computed Tomography and MR Imaging Findings in Mycotic Infections.

Fungal infections constitute a diverse spectrum of infections with variable clinical and imaging features. They are commonly opportunistic infections that affect immunocompromised individuals secondary to inherited or acquired disorders. Fungal infections may affect multiple organ systems and contribute to significant morbidity and mortality.

Prospective evaluation of selected clinical criteria for cranial computed tomography in non-trauma adult patients.

Objective: To evaluate the usefulness of previously published criteria by Rothrock et al. and Harris et al. for urgent, cranial CT in non-trauma presentations.

Dapsone-induced acute pancreatitis.

Objective: To report a case of acute pancreatitis associated with dapsone use.

Case Summary: An 87-year-old white man was prescribed dapsone for dermatitis herpetiformis. Four weeks later, he developed acute abdominal pain requiring hospitalization.