Correlation of Serum and Gingival Crevicular Fluid Levels of Caspase-3 and Milk Fat Globule-Epidermal Growth Factor 8 on Gingival Health.

Aim: This study aimed to estimate and correlate the serum and gingival crevicular fluid (GCF) levels of caspase-3 and milk fat globule-epidermal growth factor 8 (MFG-E8) in healthy, gingivitis and generalised chronic periodontitis subjects.

Materials And Methods: A total of 24 subjects were selected and divided into three groups. After recording the periodontal parameters (plaque index (PI), modified gingival index (MGI), probing depth (PD) and clinical attachment level (CAL)), the serum and GCF samples were collected and the levels of caspase-3 and MFG-E8 were estimated using enzyme-linked immunoassay (ELISA).

Herbal Interactions with Cardiac Medications: A Comprehensive Review of Potential Interactions between Herbal Drugs and Commonly Prescribed Cardiac Medications.

The concomitant use of herbal remedies in conjunction with conventional cardiac medications has increased significantly in recent years, primarily due to improvements in the quality standards of herbal medicines and the pervasive belief that natural products pose no harm to the human body. Contrary to this belief, multiple phytoconstituents found in herbal products have the potential to interact with conventional cardiac drugs, potentially resulting in severe adverse effects.

Wound healing efficacy of curcumin-loaded sandalwood bark-derived carbon nanosphere/PVA nanofiber matrix.

The present investigation deals with the evaluation of the wound healing efficacy of sandalwood bark-derived carbon nanospheres loaded with curcumin-embedded polyvinyl alcohol (PVA) nanofiber membranes (NF). Carbon nanospheres (CNS) were prepared by pyrolyzing sandal wood bark powder at 750 °C. The morphology was confirmed by field emission scanning electron micrographs and a rich amount of carbon was confirmed by the energy dispersive X-ray technique.

Effectiveness of three mouth rinsing agents against mutans and species - A comparative study.

Background: Dental caries is one of the most common chronic childhood diseases and is a cause of continuous discomfort through impaired function and esthetics. To control dental caries, the removal of plaque is of utmost importance, and that further necessitates the use of chemotherapeutic agents. Several side effects associated with chlorhexidine have stimulated the search for an alternative chemotherapeutic agent.

Design, Synthesis, Characterization, and Analysis of Antimicrobial Property of Novel Benzophenone Fused Azetidinone Derivatives through In Vitro and In Silico Approach.

A sequence of novel 2-(4-benzoyl-2-methyl-phenoxy)-N-(3-chloro-2-oxo-4-phenyl-azetidin-1-yl)-acetamide analogues 9(a−n) were synthesized by multistep synthesis. The newly synthesized compounds were well characterized, and their antimicrobial activities were carried out by disc diffusion and broth dilution methods. Further, all the novel series of compounds (9a−n), were tested against a variety of bacterial and fungal strains in comparison to Ketoconazole, Chloramphenicol, and Amoxicillin as standard drugs, respectively.

Physisorption of trichloroethylene and tetrachloroethylene on novel zeta arsenene nanotubes - A first-principles study.

The structural stability of novel ζ-arsenene nanotubes (ζ-AsNT) is studied based on the density functional theory framework and is used as a base material for the detection of trichloroethylene and tetrachloroethylene vapours. The formation energy of ζ-AsNT is found to be -4.321 eV/atom and the energy band gap is 0.

Arab-Indian -530 ß-distal promoter haplotype and sickle/Hb D heterozygosis in Badagas of Nilgiris: is it suggestive of Harappan origin?

Origin and ancestry of the Badagas of Nilgiris, an indigenous community of Nilgiris, Tamil Nadu in India, is a controversial topic. During our massive screening for haemoglobinopathies among Badagas, we identified a rare south Indian haemoglobin variant, the haemoglobin D (Hb D) Punjab (HBB: c.364G>C; rs33946267).

Influence of obturating techniques on root dentin crack propagation: A micro-computed tomography assessment.

Aim: The aim is to assess and compare the microcrack formation in radicular dentin after obturating the root canals with cold lateral condensation (CLC), warm vertical condensation (WVC), and injectable gutta-percha (IGP) techniques using micro-computed tomography (CT).

Materials And Methods: Human extracted mandibular premolar teeth ( = 60) were haphazardly assigned based on the obturation technique into three experimental groups ( = 20 each). Root canals are cleaned and shaped with M Two rotary files and 3% sodium hypochlorite irrigant.

Multidentate ligand approach for conjugation of perovskite quantum dots to biomolecules.

Building compatible surface on perovskite quantum dots (PQDs) for applications like sensing analytes in aqueous medium is highly challenging and if achieved by simple means can revolutionize disease diagnostics. The present work reports the surface engineering of CsPbBr QDs via "simple ligand exchange process" to achieve water-compatible QDs towards detection of biomolecules. The monodentate oleic acid ligand in CsPbBr QDs is exchanged with dicarboxylic acid containing (bidentate) ligands such as folic acid (FA), ethylenediamine tetra-acetic acid (EDTA), succinic acid (SA) and glutamic acid (GA) to develop an efficient water-compatible PQD-ligand system.

Simple Nested Allele-Specific approach with penultimate mismatch for precise species and sex identification of tiger and leopard.

Accurate species and sex identification of non-invasive and forensic samples of the tiger and leopard is still confusing when using the allele-specific methods. We designed allele-specific methods with penultimate nucleotide mismatch in a nested manner for the exact identification and double-checking of forensic samples. The mismatch design is a novel concept in species and sex identification, making the allele-specific targeting precise.

Direct micro-scale monitoring of molecular aggregation, its growth and diffusion via aggregation-induced emission.

Time-dependent monitoring of aggregation-induced fluorescence of a model compound namely, (Z)-3-(3',5'-bis(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-2-(4-bromophenyl)acrylonitrile unearth hitherto unknown molecular level events such as onset of molecular aggregation, their growth, size, and diffusion dynamics. The presented generalized approach can also be extended to in situ monitoring and controlling of various biological aggregation processes down to a single-cell level and all aspects of materials chemistry, as well.

Nonwoven fabric supported, chitosan membrane anchored with curcumin/TiO complex: Scaffolds for MRSA infected wound skin reconstruction.

Use of biomaterial scaffolds as drug carriers for infected wounds treatment is of wide scope. A series of curcumin/TiO complex loaded chitosan scaffolds are fabricated for the same. Synthesized wound dressing material is screened for their morphology, water absorption capacity; in vitro drug release patterns, in vitro antibacterial studies against gram +ve and a gram -ve bacteria, cell viability for 3T3-L1 cell lines as well as in vivo MRSA infected wound healing capability.

Randomized controlled trial of cefazolin monotherapy versus cefazolin plus azithromycin single dose prophylaxis for cesarean deliveries: A developing country's perspective.

Aim: To compare the efficacy of pre-incision intravenous single doses of cefazolin versus cefazolin plus azithromycin as an antibiotic prophylaxis in cesarean delivery (CD).

Methods: This was a single-center, double blind, randomized controlled trial conducted in the PGIMER, Chandigarh. 200 women undergoing elective/emergency cesarean section were randomized.

Membranes for dehydration of alcohols via pervaporation.

Alcohols are the essential chemicals used in a variety of pharmaceutical and chemical industries. The extreme purity of alcohols in many of such industrial applications is essential. Though distillation is one of the methods used conventionally to purify alcohols, the method consumes more energy and requires carcinogenic entertainers, making the process environmentally toxic.

Apoptosis-Mediated Cytotoxic Effect of var. on Colon (HT29) and Hepatic (HepG2) Cancer Cell Lines.

Introduction: var. (Wight) Grav. and Mayur.

Morphometric computer-assisted image analysis of epithelial cells in different grades of oral squamous cell carcinoma.

Introduction: Oral squamous cell carcinoma (OSCC) accounts 94% of all malignant lesions in the oral cavity. In the assessment of OSCC, nowadays the WHO grading system has been followed widely but due to its subjectivity, investigators applied the sophisticated technique of computer-assisted image analysis in the grading of carcinoma in larynx, lungs, esophagus, and cervix to make it more objective.

Aims And Objectives: Access, analyze, and compare the cellular area (CA); cytoplasmic area (Cyt A); nuclear area (NA); nuclear perimeter (NP); nuclear form factor (NF); and nuclear-cytoplasmic ratio (N/C) of the cells in different grades of OSCC.

Endodontic management of contralateral mandibular first molars with six root canals.

The knowledge of variations in root canal morphology is essential for a successful endodontic outcome. Contralateral mandibular molar with six root canals is a rare entity. Root canal treatment of mandibular molars with aberrant canal configuration can be diagnostically and technically challenging.

Novel modified poly vinyl chloride blend membranes for removal of heavy metals from mixed ion feed sample.

Herein, an attempt has been made to prepare a novel membrane with good efficiency for removal of heavy metal ions namely lead (Pb), cadmium (Cd) and chromium (Cr). 4-amino benzoic acid (ABA) was covalently grafted onto the poly vinyl chloride (PVC) backbone by CN bond to enhance the hydrophilicity. H NMR and ATR-IR spectroscopy analysis confirmed the chemical modification of PVC.

Quality by Design Approach for Simultaneous Estimation of Doxycycline Hyclate and Curcumin by RP-HPLC Method.

A simple, rapid, reliable, robust and optimized reversed phase high performance liquid chromatographic method for simultaneous estimation of doxycycline hyclate and curcumin was successfully developed and validated as per International Conference on Harmonization guidelines. The objective was achieved in terms of well separated peaks within 10 min on a Waters Sunfire C8 column with dimensions of 250×4.6 mm, particle size 5.

Study of Collagen Birefringence in Different Grades of Oral Squamous Cell Carcinoma Using Picrosirius Red and Polarized Light Microscopy.

Objectives. The present study was done to evaluate birefringence pattern of collagen fibres in different grades of oral squamous cell carcinoma using Picrosirius red stain and polarization microscopy and to determine if there is a change in collagen fibres between different grades of oral squamous cell carcinoma. Materials and Methods.

Computational Identification of MicroRNAs and Their Targets from Finger Millet (Eleusine coracana).

MicroRNAs are endogenous small RNAs regulating intrinsic normal growth and development of plant. Discovering miRNAs, their targets and further inferring their functions had become routine process to comprehend the normal biological processes of miRNAs and their roles in plant development. In this study, we used homology-based analysis with available expressed sequence tag of finger millet (Eleusine coracana) to predict conserved miRNAs.

Identification of microRNAs and their targets in Finger millet by high throughput sequencing.

MicroRNAs are short non-coding RNAs which play an important role in regulating gene expression by mRNA cleavage or by translational repression. The majority of identified miRNAs were evolutionarily conserved; however, others expressed in a species-specific manner. Finger millet is an important cereal crop; nonetheless, no practical information is available on microRNAs to date.

Preparation and Characterization of Chitosan Thin Films on Mixed-Matrix Membranes for Complete Removal of Chromium.

Herein we present a new approach for the complete removal of Cr(VI) species, through reduction of Cr(VI) to Cr(III), followed by adsorption of Cr(III). Reduction of chromium from water is an important challenge, as Cr(IV) is one of the most toxic substances emitted from industrial processes. Chitosan (CS) thin films were developed on plain polysulfone (PSf) and PSf/TiO2 membrane substrates by a temperature-induced technique using polyvinyl alcohol as a binder.

Identification and Characterization of High Temperature Stress Responsive Novel miRNAs in French Bean (Phaseolus vulgaris).

MicroRNAs are important gene regulators controlling almost all biological and metabolic functions. They elicit their regulatory response through modulation of their target gene expression. In this study, we identified eight novel microRNAs (miRNAs) belonging to four miRNA families and one miR* sequence from the French bean genome which responded to high temperature.

Photoactive titania float for disinfection of water; evaluation of cell damage by bioanalytical techniques.

A photoactive float was fabricated with the modified titania to cause a feasible disinfection of water, contaminated with E. coli. The commercially available titania was doped with neodymium by pulverization technique to enhance its activity in sunlight and a multiapproach technique was used to evaluate the extended efficiency of the doped sample.