Elevated CO ameliorates the high temperature stress effects on physio-biochemical, growth, yield traits of maize hybrids.

The rising temperatures and levels of carbon dioxide in the atmosphere are anticipated to have a significant impact on the productivity of agricultural crops. Although, the individual effects of elevated CO and temperature have been extensively studied in C3 and C4 crops, there remains a scarcity of research investigating their interactive effects specifically on maize hybrids. The impact of elevated temperature and its interaction with elevated CO on phenology, physiology, biomass, and grain yield of maize hybrids was assessed in a field experiment using Free Air Temperature Elevation (FATE) facility.

Clinical Audits to Identify Medication Errors in a Healthcare Facility.

Medication errors have serious effects on patient care and it is important to detect them instantly in order to reduce clinical practice errors and prevent their adverse outcomes. Even though error reporting techniques are less expensive, there may be considerable impediments for a nurse to notify an error due to the obvious possibility of negative repercussions. The present study was undertaken to determine the incidence of medication errors, with identifying their common types, and the effect of clinical audits.

Scrub Typhus and Dengue Co-infection in an Adolescent Girl: A Diagnostic Challenge.

Scrub typhus and dengue fever are common infectious diseases in tropical regions, and both have overlapping clinico-epidemiological and laboratory features, which often pose a diagnostic challenge. This case report discusses a 15-year-old girl from the Indian subcontinent who presented with acute undifferentiated febrile illness (AUFI) without typical features of any of the common tropical infections. She was diagnosed with co-infection of scrub typhus and dengue fever using laboratory tests with good diagnostic accuracy.

Trends in selected birth defects among parents from below poverty line population in Karnataka during 2010-2020.

The aim of the study is to reveal the common birth defects among parents of newborns belonging to the below poverty line (BPL) category in Karnataka state (South India) by analyzing Suvarna Arogya Suraksha Trust data. In the last 10 years, 3672 kids in BPL families have been born with various birth abnormalities. It is found that 50.

Depression in Patients on Hemodialysis: A Dilapidated Facet.

Introduction End-stage renal disease (ESRD) has increased in India due to the growing load of non-communicable diseases. The most prevalent psychological issue among these patients has been identified as depression, which may have an impact on treatment success. Around 20% to 90% of hemodialysis patients experience depression.

Blood Culture Contamination Rate as a Quality Indicator - a Prospective Observational Study.

Blood culture test is the gold standard test to diagnose bloodstream infections, but contamination is the main problem in this valuable test. False positive results in blood cultures are mainly due to contamination that occurs mostly during pre-analytical procedures like sample collection and sometimes during sample processing. Our prospective observational study was undertaken at St.

Nipah amidst Covid-19 Pandemic, another Re-Emerging Infectious Disease of Pandemic Potential - a Narrative Review.

Nipah virus (NiV) was reported for the first time from the Kampung Sungai Nipah village of Malaysia in 1998. Since then, there have been multiple outbreaks, all of them in South- and South-East Asia. According to the World Health Organization (WHO), up to 75% of Nipah infections were proven to be fatal.

Integrating Artificial Intelligence for Clinical and Laboratory Diagnosis - a Review.

The development of medical artificial intelligence (AI) is related to programs intended to help clinicians formulate diagnoses, make therapeutic decisions and predict outcomes. It is bringing a paradigm shift to healthcare, powered by the increasing availability of healthcare data and rapid progress in analytical techniques (1). Artificial intelligence techniques include machine learning methods for structured data, such as classical support vector machines and neural networks, modern deep learning (DL), and natural language processing for unstructured data.

Detection of Metallo Beta-Lactamase (MBL) Producing in a Tertiary Care Hospital, Ghanpur, Medchal, India.

Pseudomonas aeruginosa is a leading cause of nosocomial infections and is especially prevalent among patients with burn wounds, cystic fibrosis, acute leukemia, organ transplants and intravenous-drug addiction. Acquired metallo-â-lactamases (MBLs) are carbapenemases which require zinc in the active site and are predominantly produced by They belong to Ambler's class B and Bush-Jacoby Medeiros Group 3 and hydrolyse virtually all â-lactam agents, including the carbapenems. In India, only blaVIM and NDM-1 have been reported in Metallo beta-lactamases have recently emerged as one of the most worrisome resistance mechanisms owing to their capacity to hydrolyse all beta-lactams, including carbapenems.

Vector-Borne Diseases amidst COVID-19 Pandemic in India - A Mini-Review.

Vector-borne diseases are infections caused by parasites, viruses and bacteria and transmitted by vectors, which are usually insects. A greater risk of diseases such as dengue, malaria, seasonal influenza, leptospirosis, chikungunya, enteric fever, etc co-exist in COVID-19 cases. This poses challenges in clinical and laboratory diagnosis of COVID-19, which may affect clinical management and patient outcomes.

Comparative assessment of antioxidant and immunomodulatory properties of skimmed milk protein hydrolysates and their incorporation in beverage mix.

Background: Milk-derived protein hydrolysates have generated a great deal of interest recently due to their numerous beneficial health effects. However, there are few comparative studies on protein hydrolysates from different dairy species, their production, characterization, and bioactivity. In the present study, skimmed milk from both major and minor dairy species was hydrolyzed with alcalase, and its protein profiles were studied using tricine polyacrylamide gel electrophoresis and reverse phase-high protein liquid chromatography.

Audits of Antimicrobial Usage in a Tertiary Care Center in Hyderabad.

Background Irrational prescriptions have an ill effect on health as well as on healthcare expenditure. Prescription auditing is an important tool to improve the quality of prescriptions, which in turn improves the quality of health care provided. Regular and timely audits of antibiotic prescriptions can prevent irrational antibiotic usage.

Topographical Landmarks for the Identification of Branches of Mandibular Nerve and Its Surgical Implications: A Cadaveric Study.

Introduction Basic knowledge of anatomy is crucial in providing predictable, safe, and efficacious mandibular anesthesia as the mandibular nerve is vulnerable to injury during dental procedures and other surgical manoeuvers. The lack of availability of the appropriate topographical bony landmarks for the location of the branches of this nerve often accounts for iatrogenic injuries and the failure to obtain adequate local anesthaesia. Hence we aimed to describe the topographical landmarks of the branches of the mandibular nerve and their variations in the infratemporal fossa.

Maximising the bioaccessibility of iron and zinc of a complementary food mix through multiple strategies.

The investigation was undertaken to maximise the bioaccessibility of iron and zinc of a complementary food mix by multiple approaches of dephytinisation and addition of organic acids. A wheat, pulse and oilseed protein flour mix was dephytinized by phytase activation and different thermal treatments. As the mineral content of the mix was low, the spray dried mix was fortified with different iron and zinc salts to identify the salt with the highest bioaccessibility in this matrix.

Vaginal discharge: The diagnostic enigma.

Background: Vaginal discharge is a common clinical problem with varied etiologies, most common being bacterial vaginosis which presents as homogenous gray discharge caused by overgrowth of facultative and anaerobic bacterial species, next common is vulvovaginal candidiasis characterized by pruritus and cottage cheese like discharge followed by vaginal trichomoniasis associated with copious yellow or green and frothy discharge. This necessitates the need to identify the specific cause of vaginal discharge.

Aim: To determine the etiology of pathological vaginal discharges in women attending tertiary care hospital.

Ameliorative effect of enhanced Fischer ratio flaxseed protein hydrolysate in combination with antioxidant micronutrients on ethanol-induced hepatic damage in a rat model.

Alcohol abuse causes severe metabolic abnormalities inducing hepatic damage and malnutrition. Since higher Fischer ratio proteins have therapeutic value in liver diseases, an investigation was undertaken to study the ameliorative effect of the enhanced Fischer ratio flaxseed protein hydrolysate (EFR-FPH) alone and in combination with antioxidant micronutrients on ethanol-induced hepatotoxicity in a rat model. The EFR-FPH was prepared by dual enzymatic hydrolysis and charcoal treatment of flaxseed protein.

An Unusual Case of Candida kefyr Fungemia in an Immunocompromised Patient.

An immunocompromised patient with a known history of cerebrovascular accident (CVA) with right-sided hemiparesis of long duration, type 2 diabetes mellitus, and hypertension presented with signs of rhabdomyolysis and later acute kidney injury (AKI). He subsequently developed Guillain Barre syndrome. Initially, hemodialysis was followed by plasmapheresis.

Impaired liver regeneration and lipid homeostasis in CCl treated WDR13 deficient mice.

WDR13 - a WD repeat protein, is abundant in pancreas, liver, ovary and testis. Absence of this protein in mice has been seen to be associated with pancreatic β-cell proliferation, hyperinsulinemia and age dependent mild obesity. Previously, we have reported that the absence of WDR13 in diabetic Lepr mice helps in amelioration of fatty liver phenotype along with diabetes and systemic inflammation.

Molecular characterization of Wdr13 knockout female mice uteri: a model for human endometrial hyperplasia.

Endometrial hyperplasia (EH) is a condition where uterine endometrial glands show excessive proliferation of epithelial cells that may subsequently progress into endometrial cancer (EC). Modern lifestyle disorders such as obesity, hormonal changes and hyperinsulinemia are known risk factors for EH. A mouse strain that mimics most of these risk factors would be an ideal model to study the stage-wise progression of EH disease and develop suitable treatment strategies.

Milling interventions for the production of for Indian flat bread with low carbohydrate digestibility.

Study was aimed to produce for chapati, an Indian flat bread with low carbohydrate digestibility through different milling interventions; processing and formulating a functional ingredient mix (FM). Granulation, physico-chemical, rheological and chapati making characteristics of chakki , CA (control), roller mill (RA); RA replaced with 5, 10 and 15% FM (5, 10 and 15% RAFM) were evaluated. RA and RAFM samples showed lower water absorption, higher dough stability, pasting temperature and peak viscosity than CA.

Functional evaluation of a monotreme-specific antimicrobial protein, EchAMP, against experimentally induced mastitis in transgenic mice.

EchAMP, the tenth most abundant transcript expressed in the mammary gland of echidna, has in vitro broad-spectrum antibacterial effects. However, the effects of EchAMP on mastitis, a condition where inflammation is triggered following mammary gland infection, has not been investigated. To investigate the impact of EchAMP against mastitis, EchAMP transgenic mice were generated.

Wdr13 and streptozotocin-induced diabetes.

Type I diabetes, though contributes to only 5-10% of total diabetes cases, is a rising concern in today's world. Our previous studies have shown that the absence of WDR13 in mouse results in pancreatic β-cell hyper-proliferation. Also, amelioration of the diabetic phenotype on introgression of Wdr13-null (Wdr13) mutation in genetically diabetic mice (Lepr) [type II diabetes] was observed.

Poverty and Community-Acquired Antimicrobial Resistance with Extended-Spectrum β-Lactamase-Producing Organisms, Hyderabad, India.

The decreasing effectiveness of antimicrobial agents is a global public health threat, yet risk factors for community-acquired antimicrobial resistance (CA-AMR) in low-income settings have not been clearly elucidated. Our aim was to identify risk factors for CA-AMR with extended-spectrum β-lactamase (ESBL)-producing organisms among urban-dwelling women in India. We collected microbiological and survey data in an observational study of primigravidae women in a public hospital in Hyderabad, India.

Absence of Gene Predisposes Mice to Mild Social Isolation - Chronic Stress, Leading to Depression-Like Phenotype Associated With Differential Expression of Synaptic Proteins.

We earlier reported that the male mice lacking the gene () showed mild anxiety, better memory retention, and up-regulation of synaptic proteins in the hippocampus. With increasing evidences from parallel studies in our laboratory about the possible role of in stress response, we investigated its role in brain. We observed that transcript gets up-regulated in the hippocampus of the wild-type mice exposed to stress.