Publications by authors named "Jyh Y Chwee"
Apoptosis is a controlled means of eliminating damaged cells without causing an inflammatory response or tissue damage. The mechanisms that contribute to the suppression of an inflammatory response upon apoptosis of cells are poorly understood. Here, we report that apoptotic cells release the interleukin-1 receptor antagonist (IL1RA).
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- The study aims to improve cancer immunotherapy by testing whether combining TLR agonists with chemotherapy can make tumor cells more recognizable to the immune system.
- Treatment with the TLR1/2 agonist Pam3CSK4 alongside chemotherapy agent Ara-C increased the survival of mice and boosted the tumor-fighting effects compared to using either treatment alone.
- The findings suggest that this combination enhances the expression of immune-related molecules in B-cell lymphoma cells, thus improving their immunogenicity and reliance on immune cells for tumor rejection.
Natural killer (NK) cells are able to lyse infected and tumor cells while sparing healthy cells. Recognition of diseased cells by NK cells is governed by several activating and inhibitory receptors. We review numerous pathways that have been implicated in the regulation of self-ligands for activating receptors, including NKG2D, DNAM-1, LFA-1, NKp30, NKp44, NKp46, NKp65, and NKp80 found on NK cells and some T cells.
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