Synthesis, Characterization, Antitubercular Activity, and Molecular Docking Studies of Pyrazolylpyrazoline-Clubbed Triazole and Tetrazole Hybrids.

To increase the antitubercular potency, we synthesized a series of novel pyrazolylpyrazoline derivatives (-) using the one-pot multicomponent reaction of the substituted heteroaryl aldehyde (,), 2-acetyl pyrrole/thiazole (,), and substituted hydrazine hydrates (-) in the presence of base NaOH as a catalyst in ethanol as the solvent at room temperature. Substituted heteroaryl aldehyde (,) was synthesized from 5-chloro-3-methyl-1-phenyl-1-pyrazole-4-methyl-carbaldehyde on protection with ethylene glycol followed by treatment with 4-amino triazole/5-amino tetrazole and then deprotection using acid. The salient features of the green protocol are the one-pot reaction, shorter reaction time, and straightforward workup procedure.