Effects of 4-hexylresorcinol on facial skeletal development in growing rats: Considerations for diabetes.

Objective: : To investigate the long-term effects of 4-hexylresorcinol (4HR) on facial skeletal growth in growing male rats, with a focus on diabetic animal models.

Methods: : Forty male rats were used. Of them, type 1 diabetes mellitus was induced in 20 animals by administering 40 mg/kg streptozotocin (STZ), and they were assigned to either the STZ or 4HR-injected group (STZ/4HR group).

Relevant Properties and Potential Applications of Sericin in Bone Regeneration.

The potential of sericin, a protein derived from silkworms, is explored in bone graft applications. Sericin's biocompatibility, hydrophilic nature, and cost-effectiveness make it a promising candidate for enhancing traditional graft materials. Its antioxidant, anti-inflammatory, and UV-resistant properties contribute to a healthier bone-healing environment, and its incorporation into 3D-printed grafts could lead to personalized medical solutions.

Denosumab-associated jaw bone necrosis in cancer patients: retrospective descriptive case series study.

Background: Denosumab (DMB) is a bone antiresorptive agent used to treat osteoporosis or metastatic cancer of the bones. However, denosumab-associated osteonecrosis of the jaw (DRONJ) has become a common complication in cancer patients. The prevalence of osteonecrosis of the jaw (ONJ) in cancer patients is estimated to be similar for both bisphosphonate-related cases (1.

The Effect of Buccal Fat Pad Graft in the Palatoplasty and the Risk Factor of Postoperative Palatal Fistula.

Purpose: The aim of this study was to evaluate the effect of buccal fat pad (BFP) in the palatoplasty and to investigate the risk factors associated with postoperative palatal fistula formation.

Materials And Methods: Sixty-five cleft palate patients were enrolled for this study. Clinical data regarding sex, age, type of cleft, surgical technique, the ratio of cleft width, and BFP graft were collected.

Retrospective comparative clinical study for silk mat application into extraction socket.

Background: Silk mats have been approved for clinical trials by the Korean Food and Drug Administration as membranes for guided tissue regeneration (GTR). In this study, silk mat application was compared to high-density polytetrafluoroethylene (dPTFE) membrane application or no membrane group.

Methods: To compare the silk mat group to the dPTFE group or the no membrane group, a retrospective sample collection was conducted.

Accelerated biodegradation of silk sutures through matrix metalloproteinase activation by incorporating 4-hexylresorcinol.

Silk suture material is primarily composed of silk fibroin and regarded as a non-resorbable material. It is slowly degraded by proteolysis when it is implanted into the body. 4-Hexylresorcinol (4HR) is a well-known antiseptic.

A New Method of Fixation With the Yang's Keyhole Plate System for the Treatment of Mandible Fractures.

Purpose: This study was designed to assess the clinical outcomes and surgical convenience of a newly designed Yang's Keyhole plate (YK plate) system for treatment of subcondyle and angle fractures of the mandible. To evaluate the system's clinical outcomes and surgical convenience, chart review and surgical simulation using a mandible replica model were performed.

Methods: The YK plate system, which is a slightly modified sliding plate, has 0.

Surgically assisted rapid palatal expansion with tent screws and a custom-made palatal expander: a case report.

Rapid palatal expansion(RPE) with the tooth-born appliance is not sufficient to apply to the patients with periodontal problem or insufficient tooth anchorage, and it leads to tipping of the anchorage teeth and increasing teeth mobility and root resorption. To avoid these disadvantages, we present the case using palatal screws and custommade palatal expander. A 23-year-old patient underwent surgically assisted rapid maxillary expansion with the Hyrax expansion using 4 tent screws.

Comparable efficacy of silk fibroin with the collagen membranes for guided bone regeneration in rat calvarial defects.

Purpose: Silk fibroin (SF) is a new degradable barrier membrane for guided bone regeneration (GBR) that can reduce the risk of pathogen transmission and the high costs associated with the use of collagen membranes. This study compared the efficacy of SF membranes on GBR with collagen membranes (Bio-Gide®) using a rat calvarial defect model.

Materials And Methods: Thirty-six male Sprague Dawley rats with two 5 mm-sized circular defects in the calvarial bone were prepared (n=72).

Design and application of hybrid maxillomandibular fixation for facial bone fractures.

Purpose: A novel maxillomandibular fixation (MMF) procedure using a skeletal anchorage screw (SAS) (in the maxilla) and an arch bar (in the mandible), which we call "hybrid maxillomandibular fixation," was explored in this study. The aims of the study were to examine the efficacy of our hybrid MMF method and to compare periodontal tissue health and occlusal rehabilitation among 3 MMF methods.

Materials And Methods: In total, 112 patients who had undergone open reduction at the Department of Oral and Maxillofacial Surgery between September 2005 and December 2012 were selected for this study.

Condylar repositioning in bilateral sagittal split ramus osteotomy with centric relation bite.

Purpose: Changes in the condylar position after bilateral sagittal split ramus osteotomy (BSSO) can cause many complications, such as condylar dysfunction and increased risk of relapse. This study evaluated a simple approach for condylar repositioning in BSSO as a method to rapidly obtain the patient's centric relation (CR) bite position without prefabricated equipment.

Methods: The study subjects included 9 patients (5 men and 4 women; mean age, 23.

Condylar repositioning using centric relation bite in bimaxillary surgery.

Objective: The purpose of this study was to evaluate displacement of the mandibular condyle after orthognathic surgery using a condylar-repositioning device.

Methods: The patient group comprised 20 adults who underwent bimaxillary surgery between August 2008 and July 2011. The degree of condylar displacement was measured by pre- and postoperative tomographic analysis using centric relation bite and a wire during surgery.

Cisplatin and 4-hexylresorcinol synergise to decrease metastasis and increase survival rate in an oral mucosal melanoma xenograft model: a preliminary study.

The present study was undertaken to examine the effects of cisplatin plus 4-hexylresorcinol (4-HR) combination therapy on oral mucosal melanoma (OMM) using cultured primary OMM cells in a tumour xenograft model. Cultured primary OMM cells were used for the MTT assay and DNA microarray. OMM cells were implanted into the submandibular glands of nude mice.

Restoration of a peri-implant defect by platelet-rich fibrin.

Objective: The objective of this study was to evaluate the application of platelet-rich fibrin (PRF) into a peri-implant defect in vivo.

Study Design: Eight New Zealand white rabbits were used for this study. Two peri-implants with defects sized 3.

Accelerated healing with the use of a silk fibroin membrane for the guided bone regeneration technique.

Objective: The purpose of this study was to evaluate the bone regeneration ability of silk fibroin (SF) membrane.

Study Design: Fourier-transform infrared (FT-IR) and solubility test against distilled water were performed with 3 different types of SF membrane (SM1, SM2, and SM3). Subsequently, microscopic computerized tomography (μ-CT) and histomorphometric analyses were performed in rabbit calvarial defect model after SF membrane application at 4 and 8 weeks after surgery.

Development of nano-hydroxyapatite graft with silk fibroin scaffold as a new bone substitute.

Purpose: This study involves a comparison between the bone regeneration of nano-hydroxyapatite (nHA), as derived from eggshells either with or without silk fibroin scaffolds, and the unfilled control in the rabbit calvarial bony defect model.

Materials And Methods: Sixteen 4-month-old New Zealand white rabbits, with a mean weight of 2.8 kg (range, 2.

Effects of installation depth on survival of an hydroxyapatite-coated Bicon implant for single-tooth restoration.

Purpose: The present retrospective study evaluated various implant surface factors associated with Bicon implant survival for single-tooth restoration in the healthy individual.

Patients And Methods: A retrospective cohort study design was used. A total of 613 Bicon (Bicon System, Boston, MA) implants (272 patients) were included.

A combination graft of low-molecular-weight silk fibroin with Choukroun platelet-rich fibrin for rabbit calvarial defect.

Objective: The objective of this study was to determine the capabilities of silk fibroin as a biomaterial template for bone formation when mixed with Choukroun platelet-rich fibrin (PRF) in vivo.

Study Design: Ten New Zealand white rabbits were used for this study and bilateral round shaped defects were formed in the parietal bone (diameter 9.0 mm).

Low molecular weight silk fibroin increases alkaline phosphatase and type I collagen expression in MG63 cells.

Silk fibroin, produced by the silkworm Bombyx mori, has been widely studied as a scaffold in tissue engineering. Although it has been shown to be slowly biodegradable, cellular responses to degraded silk fibroin fragments are largely unknown. In this study, silk fibroin was added to MG-63 cell cultures, and changes in gene expression in the MG-63 cells were screened by DNA microarray analysis.