Publications by authors named "Juxia Liu"
Article Synopsis
- The study investigates how Osteopontin (OPN) influences macroautophagy, autophagy, and neuroplasticity in the brain after a stroke.
- Researchers induced a focal stroke in mice and assessed the effects of OPN on motor function, neuroplasticity markers, and autophagy-related proteins.
- Results showed that OPN treatment improved motor function and enhanced neural repair by increasing key proteins involved in synaptic plasticity and autophagy, suggesting OPN might be a new therapeutic approach for stroke recovery.
Iron accumulates in the brain with age and catalyzes free radical damage to neurons, thus playing a pathogenic role in Alzheimer's disease (AD). To decrease the incidence of AD, we synthesized the iron-affinitive peptide 5YHEDA to scavenge the excess iron in the senile brain. However, the blood-brain barrier (BBB) blocks the entrance of macromolecules into the brain, thus decreasing the therapeutic effects.
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