MicroRNA-99b Regulates Bacillus Calmette-Guerin-Infected Immature Dendritic Cell-Induced CD4+ T Cell Differentiation by Targeting mTOR Signaling.

This study aimed to elucidate the mechanisms by which microRNA-99b (miR-99b) regulates CD4+ T cell differentiation induced by Bacillus Calmette-Guerin (BCG)-infected immature dendritic cells (imDCs). Levels of miR-99b, interferon-gamma (IFN-γ), Foxp3, interleukin (IL)-10, IL-17, IL-23, and ROR-γt were assessed. Effects of miR-99b inhibition and mechanistic target of rapamycin (mTOR) agonist on Th17/Treg cell ratio and cytokine levels (IL-6, IL-17, IL-23) were studied.

Interleukin 4 gene polymorphisms and the risk of tuberculosis: A meta-analysis.

Background: Interleukin-4 (IL-4) is implicated in the progression of tuberculosis (TB); however, these results remain controversial.

Objectives: This meta-analysis examined the relationship between IL and 4 polymorphisms (-589C/T, +4221C > A, and -33C/T) and the risk of TB.

Methods: A retrospective database analysis was conducted using the CNKI and PubMed databases.

Solanine Inhibits Immune Escape Mediated by Hepatoma Treg Cells via the TGF/Smad Signaling Pathway.

Objective: To observe the inhibitory effect of solanine on regulatory T cells (Treg) in transplanted hepatoma mice and to study the mechanism of solanine inhibiting tumor growth.

Methods: The levels of Treg cells and IL-2, IL-10, and TGF in the blood of patients with liver cancer were detected by flow cytometry and ELISA, respectively. A mouse hepatocellular carcinoma (HCC) graft model was established and randomly divided into four groups: control group, solanine group, TGF inhibitor group (SB-431542), and solanine TGF inhibitor combined group.

Certain interleukin polymorphisms might influence predisposition to lung cancer: A meta-analysis of 35 published studies.

Interleukin polymorphisms might influence predisposition to lung cancer (LC), but the results of already published studies regarding the relationship between interleukin polymorphisms and LC were still controversial and ambiguous. So the authors designed this meta-analysis to more precisely estimate relationship between interleukin polymorphisms and LC by pooling the results of already published related studies. The authors searched Pubmed, Embase, Web of Science, and CNKI for already published studies.

[Adjuvant function of guilu erxian glue cataplasm in treating carcinoma of the large intestine patients with myelosuppression after chemotherapy: a clinical observation].

Objective: To observe the clinical effect of Guilu Erxian Glue Cataplasm (GEGC) on carcinoma of the large intestine patients with myelosuppression after chemotherapy, and further to confirm its efficiency and safety.

Methods: Totally 60 patients with carcinoma of the large intestine were randomly assigned to two groups. Meanwhile, they all accepted FOLFIRI chemotherapy.

[A new method for concentration determination of crude oil sample using three-dimensional synchronous fluorescence spectra].

In the spectral investigation of crude oil samples, it has been found that the synchronous fluorescence spectra (SFS) of the crude oil sample varied with the concentration in both the intensity and the location of peaks. Considering the information about both the changes in SFS, a new method for the concentration determination of crude oil sample using three-dimensional synchronous fluorescence was developed and introduced in the present paper. A number of samples have been investigated to verify the feasibility of the method.

[Fluorescence analysis of crude oil samples with different spectral approaches].

Fluorescence techniques based on emission spectrum, synchronous fluorescence spectrum (SFS), or three-dimensional (3D) fluorescence spectrum, have been widely used in medical, biological and chemical analyses. In the present paper, 25 crude oil samples from 15 different borefields in the concentration range from 10(-4) g x L(-1) to 10 g x L(-1) have been investigated with different spectral approaches. It was shown that, compared with conventional emission spectrum based technique used in oil logging, the 3D fluorescence technique can provide much more information in the analysis of crude oil samples but at the price of time consuming.