Publications by authors named "Juwann Moss"
Lipomatous Metaplasia Facilitates Ventricular Tachycardia in Patients With Nonischemic Cardiomyopathy.
JACC Clin Electrophysiol
November 2024
Article Synopsis
- The study investigates the role of lipomatous metaplasia (LM) as a critical anatomical feature in the pathways that lead to ventricular tachycardia (VT) in patients with nonischemic cardiomyopathy (NICM).
- Researchers analyzed cardiac MRI and electroanatomical maps from 49 patients, revealing that VT corridors had significantly higher volumes of LM.
- The findings suggest that these VT corridors not only contain more LM but also show lower variability in current amplitude, indicating that LM may help stabilize electrical signaling during VT episodes.
Article Synopsis
- - The study focuses on patients with nonischemic cardiomyopathy (NICM) and ventricular tachycardia (VT), aiming to explore the prevalence of lipomatous metaplasia (LM) and its effect on VT recurrence after ablation treatment.
- - Researchers analyzed 113 NICM patients who had undergone VT ablation, finding that 100% of those with VT recurrence had LM, while only 57% of control patients without VT showed LM.
- - The extent of LM was identified as a significant predictor for VT recurrence; patients with more than 2.5 grams of LM were nearly five times more likely to experience recurrence compared to those with less.
Background: Regional myocardial conduction velocity (CV) dispersion has not been studied in postinfarct patients with ventricular tachycardia (VT).
Objectives: This study sought to compare the following: 1) the association of CV dispersion vs repolarization dispersion with VT circuit sites; and 2) myocardial lipomatous metaplasia (LM) vs fibrosis as the anatomic substrate for CV dispersion.
Methods: Among 33 postinfarct patients with VT, we characterized dense and border zone infarct tissue by late gadolinium enhancement cardiac magnetic resonance, and LM by computed tomography, with both images registered with electroanatomic maps.
Background: Myocardial lipomatous metaplasia (LM) has been reported to be associated with post-infarct ventricular tachycardia (VT) circuitry.
Objectives: This study examined the association of scar versus LM composition with impulse conduction velocity (CV) in putative VT corridors that traverse the infarct zone in post-infarct patients.
Methods: The cohort included 31 post-infarct patients from the prospective INFINITY (Intra-Myocardial Fat Deposition and Ventricular Tachycardia in Cardiomyopathy) study.
Aims: Post-infarct myocardium contains viable corridors traversing scar or lipomatous metaplasia (LM). Ventricular tachycardia (VT) circuitry has been separately reported to associate with corridors that traverse LM and with repolarization heterogeneity. We examined the association of corridor activation recovery interval (ARI) and ARI dispersion with surrounding tissue type.
View Article and Find Full Text PDFBackground: Early studies suggest that coronavirus disease 2019 (COVID-19) is associated with a high incidence of cardiac arrhythmias. Severe acute respiratory syndrome coronavirus 2 infection may cause injury to cardiac myocytes and increase arrhythmia risk.
Objectives: The purpose of this study was to evaluate the risk of cardiac arrest and arrhythmias including incident atrial fibrillation (AF), bradyarrhythmias, and nonsustained ventricular tachycardia (NSVT) in a large urban population hospitalized for COVID-19.