Publications by authors named "Juwan Kim"
Exploring the combined effects of serum tumor necrosis factor-alpha and serotonin on antidepressant efficacy in depression: A 12-week prospective analysis.
Prog Neuropsychopharmacol Biol Psychiatry
March 2025
Background: This study investigated the interplay between serum tumor necrosis factor-alpha (sTNF-α) and serotonin (s5-HT) levels in predicting 12-week antidepressant treatment outcomes among patients with depressive disorders.
Methods: We analyzed baseline sTNF-α and s5-HT levels in 1086 patients enrolled in a naturalistic study of stepwise antidepressant treatment. Remission was defined as achieving a Hamilton Depression Rating Scale score of 7 or less at 12 weeks.
Backgrounds/aims: Balancing surgical risks and benefits is crucial for managing non-functional pancreatic neuroendocrine tumors (NF-PNETs). Despite high postoperative pancreatic fistula (POPF) rates, studies on postoperative complications of sporadic NFPNETs are scarce. Thus, this study aimed to investigate postoperative complications and identify risk factors for POPF.
View Article and Find Full Text PDFObjective: Despite increasing research on digital technologies for psychiatric disorders, studies specifically examining self-monitoring of symptoms with smartphone applications by patients with schizophrenia remain limited. This study aims to evaluate the validity and reliability of self-monitoring psychiatric symptoms using a smartphone application among patients with schizophrenia at Mindlink, a community-based early intervention center.
Methods: Fifty-three young patients with schizophrenia spectrum disorders participated.
Objective: Stigma influences perceptions of mental illness and novel diseases like coronavirus disease-2019 (COVID-19), often impeding healthcare access despite advancements in medical treatment. This study compares the stigma associated with COVID-19 and mental illness to identify factors that could help reduce stigma.
Methods: An online survey was conducted in May 2023 among 1,500 participants aged 19 to 65 in South Korea, using a panel from Embrain, an online survey service.
Objective: This study investigated how educational levels modify the relationship between the standard deviation of NN intervals (SDNN) of heart rate variability and the development of post-traumatic stress disorder (PTSD).
Methods: Participants with physical injuries were enrolled from a trauma center and monitored over two years. Initial assessments included SDNN and educational attainment, along with socio-demographic and clinical variables.
Introduction: This study examined the moderating effects of childhood abuse histories on the associations between low frequency (LF) and high frequency (HF) components of heart rate variability (HRV) and the development of post-traumatic stress disorder (PTSD).
Methods: Participants with physical injuries were recruited from a trauma center and followed for two years. Baseline assessments included LF, HF, and childhood abuse histories, assessed using the Nemesis Childhood Trauma Interview.
Background: This study aimed to evaluate the potential additive effects of measuring serum interleukin-1 beta (IL-1β) and interleukin-6 (IL-6) on enhancing the predictive value of baseline serum high-sensitivity C-reactive protein (hsCRP) levels for predicting 12-week antidepressant treatment responses in patients with depressive disorders.
Methods: Serum levels of hsCRP, IL-1β, and IL-6 were measured at baseline in 1086 outpatient participants diagnosed with depressive disorders. Participants initially received monotherapy with antidepressants for the first three weeks, followed by a naturalistic, stepwise pharmacotherapy regimen administered every three weeks up to 12 weeks.
Background: Pancreatic neuroendocrine tumors (PNETs) are the leading cause of death related to multiple endocrine neoplasia type 1 (MEN1). Previous studies have linked certain mutations in the MEN1 gene and loss of interactions with MENIN's functional partners to the mortality or aggressiveness of PNETs. This study aimed to evaluate the genotype-phenotype correlations of MEN1-related PNETs in Korean patients and to summarize the treatment outcomes comprehensively.
View Article and Find Full Text PDFArticle Synopsis
- This longitudinal study analyzed how serum Brain-Derived Neurotrophic Factor (sBDNF) levels and childhood adversities affect the development of Post-Traumatic Stress Disorder (PTSD) in individuals with physical injuries over two years.
- Researchers assessed patients at a trauma center for sBDNF levels and childhood adversities using the ACE questionnaire and diagnosed PTSD at multiple intervals employing the Clinician-Administered PTSD Scale.
- Results showed that lower sBDNF levels increased the risk of earlier-onset PTSD among those who experienced childhood adversities, highlighting the importance of both biological and environmental factors in PTSD development.
Article Synopsis
- * Out of 538 participants, 58 (10.8%) developed PTSD, with rates decreasing over time from 8.4% at 3 months to 2.5% at 24 months.
- * Results showed that lower SDNN was linked to PTSD in patients who did not undergo surgery, suggesting that PTSD prevention strategies should take both SDNN levels and surgical status into account.
Background: This study investigated the longitudinal associations between serum BDNF (sBDNF) levels measured early after injury and the onset of post-traumatic stress disorder (PTSD) across two years.
Methods: Patients with moderate to severe physical injuries were enrolled from a trauma center. At baseline, sBDNF levels were measured and a comprehensive socio-demographic and clinical data were collected.
Article Synopsis
- The Clinician-Administered PTSD Scale (CAPS-5) is a reliable tool for diagnosing PTSD and was used in this study to assess its predictive value for PTSD development in patients with moderate to severe physical injuries over a 2-year period.
- 1,142 patients were evaluated for acute stress disorder at baseline, and follow-up assessments were conducted at multiple intervals using CAPS-5 to track PTSD development.
- Results indicated that while baseline CAPS-5 diagnoses showed limited predictive ability, scores of 15 or higher effectively predicted later PTSD, with scores of 16 or higher further increasing accuracy, especially in patients with intentional injuries or prior trauma.
Article Synopsis
- The study investigated how serum cortisol levels and personality traits impact the risk of developing PTSD over two years in individuals with physical injuries.
- It involved tracking 923 patients from a trauma center, measuring their cortisol levels and personality traits, while diagnosing PTSD at multiple intervals, showing that overall PTSD rates decreased over time.
- A significant finding revealed that lower cortisol levels combined with higher Neuroticism increased PTSD risk, especially in the early months, highlighting the complex relationship between biological factors and personality in PTSD development.
Delayed effects of alcohol consumption on the association between serum BDNF levels and post-traumatic stress disorder development over two-years.
Prog Neuropsychopharmacol Biol Psychiatry
December 2024
Article Synopsis
- This study investigated how serum BDNF (sBDNF) levels and alcohol consumption status affect the risk of developing PTSD after a physical injury over a two-year period.
- It involved 923 trauma center participants, with 12.1% developing PTSD, revealing that lower sBDNF levels were linked to PTSD in alcohol consumers, but not in non-drinkers.
- The findings suggest a crucial interaction between sBDNF and alcohol consumption in predicting PTSD, emphasizing the importance of considering these factors in prevention strategies, although the study’s focus on a single trauma center may affect overall applicability.
Article Synopsis
- - The study explored factors that predict early-onset (within 6 months) and delayed-onset (after 6 months) PTSD in patients following physical injuries over two years.
- - Data was collected from 1142 patients in South Korea, assessing various personal, trauma-related, and psychological factors, with diagnoses made using the Clinician-administered PTSD Scale at multiple follow-up points.
- - Results showed that early-onset PTSD was more likely in individuals with previous psychiatric issues and higher anxiety, while delayed-onset PTSD was associated with greater injury severity and life stressors, highlighting the need for tailored interventions.
Background: Pancreatic neuroendocrine tumors (PNETs) represent 1-2% of pancreatic tumors, with recent guidelines recommending active surveillance for non-functioning PNETs (NF-PNETs) smaller than 2 cm. However, the management of multiple NF-PNETs, as well as the influence of tumor number on prognosis, remains under-researched.
Methods: This retrospective study analyzed NF-PNET patients who underwent pancreatic resection at Severance Hospital between February 1993 and August 2023, comparing the characteristics of patients diagnosed with multifocal tumors and those with unifocal tumors.