Publications by authors named "Justyna Socha"
The N-methyl-D-aspartate (NMDA) glutamate receptor is a major target of ethanol, and it is implicated in learning and memory formation, and other cognitive functions. Glycine acts as a co-agonist for this receptor. We examined whether Org24598, a selective inhibitor of glycine transporter1 (GlyT1), affects ethanol withdrawal-induced deficits in recognition memory (Novel Object Recognition (NOR) task) and spatial memory (Barnes Maze (BM) task) in rats, and whether the NMDA receptor glycine site participates in this phenomenon.
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- The study investigates the effects of Cannabidiol (CBD) on drug-taking behavior in adolescent rats, particularly focusing on its potential to reduce the reinstatement of oxycodone-induced conditioned place preference (CPP).
- Findings indicate that CBD effectively prevents reinstatement of CPP only in adolescent males, linked to changes in specific brain receptors (increased cannabinoid 1 and decreased mu opioid receptors), while similar effects were not observed in females.
- The research suggests that CBD may have gender-specific impacts on opioid-seeking behavior and cognition, emphasizing the need for further studies to understand these differences better.
Article Synopsis
- Children with fetal alcohol spectrum disorders (FASDs) show social functioning issues that lead to school withdrawal, delinquency, and increased anxiety and depression.
- A study using rats found that those exposed to ethanol at birth displayed specific social recognition memory deficits linked to age and sex.
- Treatment with CE-123, a dopamine reuptake inhibitor, helped prevent these social deficits and increased neuroplasticity in the hippocampus of the affected rats, suggesting potential for treating FASD-related social behavior problems.
2,2,6,6-Tetra-methyl-piperidinium triisopropoxysilanethiol-ate.
Acta Crystallogr Sect E Struct Rep Online
October 2009
The crystal of the title compound, C(9)H(20)N(+)·C(9)H(21)O(3)SSi(-), is built of aggregates, each made up of two 2,2,6,6-tetra-methyl-piperidinium cations and two triisopropoxysilanethiol-ate anions. The aggregates are linked by four N-H⋯S bonds and correspond to an R(2) (4)(8) graph-set motif.
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