Pro-inflammatory properties of aureocin A53.

Aureocin A53 is a peptide bacteriocin produced by an opportunistic pathogen Staphylococcus aureus strain A53. The spatial structure of aureocin, unlike its amino acid sequence, is similar to the bacteriocin BacSp222, which was recently found to have the ability to induce the inflammatory response in the host cells. The presented research aimed to verify such properties also for aureocin A53.

Immune priming modulates and interaction. Antimicrobial properties of Kazal peptide Pr13a.

larvae repeatedly infected with bacteria re-induced their immune response. Its parameters, i.e.

Defence response of Galleria mellonella larvae to oral and intrahemocelic infection with Pseudomonasentomophila.

We report differences in the course of infection of G. mellonella larvae with P. entomophila via intrahemocelic and oral routes.

BacSp222 bacteriocin as a novel ligand for TLR2/TLR6 heterodimer.

Objective And Design: BacSp222 bacteriocin is a bactericidal and proinflammatory peptide stimulating immune cells to produce selected cytokines and NO in NF-ĸB dependent manner. This study aims to identify the receptor which mediates this activity.

Methods: We applied fluorescently labeled BacSp222 and a confocal microscopy imaging to analyze the direct interaction of the bacteriocin with the cells.