Design, clinical applications and post-surgical assessment of bioresorbable 3D-printed craniofacial composite implants.

This study details the design, fabrication, clinical trials' evaluation, and analysis after the clinical application of 3D-printed bone reconstruction implants made of nHAp@PLDLLA [nanohydroxyapatite@poly(L-lactide--D,L-lactide)] biomaterial. The 3D-printed formulations have been tested as bone reconstruction in 3 different medical cases, including frontal lobe, mandibular bone, and cleft palate reconstructions. Replacing one of the implants after 6 months provided a unique opportunity to evaluate the post-surgical implant obtained from a human patient.

Multi-element analysis of metals in human pathological and unchanged thyroid glands - pilot study.

Disturbances in the homeostasis of the elemental composition of thyroid tissue may have serious metabolic and health consequences. It is believed that the accumulation of some metals or the deficiency of others may even cause lethal tumours. Due to the fact that metallomics most often uses human serum to analyse macro and microelements as well as trace elements, it was decided to use material that is more difficult to obtain, but also adds credibility to the research - thyroid tissue samples biopsy.

The Study of Nanosized Silicate-Substituted Hydroxyapatites Co-Doped with Sr and Zn Ions Related to Their Influence on Biological Activities.

Nanosized silicate-substituted hydroxyapatites, characterized by the general formula CaSrZn(PO)(SiO)(OH) (where: n = 0.2 [mol%]; x = 0.5-3.

Culture Media Composition Influences the Antibacterial Effect of Silver, Cupric, and Zinc Ions against .

Different metals, such as silver (Ag), copper (Cu), and zinc (Zn), have been broadly investigated as metals and cations used both in medicine and everyday life due to their broad spectrum of antibacterial activity. Although the antibacterial action of those metals and their ions is well known and studied, the main problem remains in the standardization of experimental procedures to determine the antimicrobial activity as bacteriological media composition might significantly influence the outcome. The presented study aimed to evaluate the appropriability of different culture media (four nutritionally rich and four minimal) in the testing of the antibacterial activity of Ag, Cu, and Zn ions against Our investigation revealed the influence of medium ingredients and the presence of phosphates, which significantly reduced the activity of tested metal ions.

Multifunctionality of Nanosized Calcium Apatite Dual-Doped with Li/Eu Ions Related to Cell Culture Studies and Cytotoxicity Evaluation In Vitro.

Li/Eu dual-doped calcium apatite analogues were fabricated using a microwave stimulated hydrothermal technique. XRPD, FT-IR, micro-Raman spectroscopy, TEM and SAED measurements indicated that obtained apatites are single-phased, crystallize with a hexagonal structure, have similar morphology and nanometric size as well as show red luminescence. Lithium effectively modifies the local symmetry of optical active sites and, thus, affects the emission efficiency.

New Approach to Antifungal Activity of Fluconazole Incorporated into the Porous 6-Anhydro-α-l-Galacto-β-d-Galactan Structures Modified with Nanohydroxyapatite for Chronic-Wound Treatments-In Vitro Evaluation.

New fluconazole-loaded, 6-Anhydro-α-l-Galacto-β-d-Galactan hydrogels incorporated with nanohydroxyapatite were prepared and their physicochemical features (XRD, X-ray Diffraction; SEM-EDS, Scanning Electron Microscopy-Energy Dispersive X-ray Spectroscopy; ATR-FTIR, Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy), fluconazole release profiles and enzymatic degradation were determined. Antifungal activity of pure fluconazole was tested using species (, , ), species (, ) and species (, ) reference strains and clinical isolates. Standard microdilution method was applied, and fluconazole concentrations of 2-250 µg/mL were tested.

Application of Selected Nanomaterials and Ozone in Modern Clinical Dentistry.

This review is an attempt to summarize current research on ozone, titanium dioxide (TiO), silver (Ag), copper oxide CuO and platinum (Pt) nanoparticles (NPs). These agents can be used in various fields of dentistry such as conservative dentistry, endodontic, prosthetic or dental surgery. Nanotechnology and ozone can facilitate the dentist's work by providing antimicrobial properties to dental materials or ensuring a decontaminated work area.

Preparation of a New Biocomposite Designed for Cartilage Grafting with Antibiofilm Activity.

New polymer-inorganic composites with antibiofilm features based on the granulated poly(tetrafluoroethylene) (PTFE) and apatite materials were obtained using a standard hydraulic press. The study was performed in hydroxy- and fluorapatites doped with different amounts of silver ions and followed by heat treatment at 600 °C. The structural, morphological, and physicochemical properties were determined by X-ray powder diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscopy-energy-dispersive spectrometry (SEM-EDS), and transition electron microscopy (TEM).

Preparation and Characterization of Self-Assembled Poly(l-Lactide) on the Surface of β-Tricalcium Diphosphate(V) for Bone Tissue Theranostics.

This work was aimed to obtain and characterize the well-defined biocomposites based on β-tricalcium diphosphate(V) (β-TCP) co-doped with Ce and Pr ions modified by poly(l-lactide) (PLLA) with precise tailored chain length and different phosphate to polymer ratio. The composites as well as β-tricalcium diphosphate(V) were spectroscopically characterized using emission spectroscopy and luminescence kinetics. Morphological and structural properties were studied using X-Ray Diffraction (XRD) and Scanning Electron Microscopy (SEM).

Structural modification of nanohydroxyapatite Ca(PO)(OH) related to Eu and Sr ions doping and its spectroscopic and antimicrobial properties.

The Eu and Sr ions co-doped hydroxyapatite nanopowders (Ca(PO)(OH)) were synthesized via a precipitation method and post heat-treated at 500 °C. The concentration of Eu ions was established in the range of 0.5-5 mol% to investigate the site occupancy preference.

Activity of gemini quaternary ammonium salts against microorganisms.

Quaternary ammonium salts (QAS), as the surface active compounds, are widely used in medicine and industry. Their common application is responsible for the development of microbial resistance to QAS. To overcome, this issue novel surfactants, including gemini-type ones, were developed.