Eplerenone promotes alternative activation in human monocyte-derived macrophages.

Background: In this study, we have analyzed the response of human monocyte-derived macrophages to mineralocorticoid axis modulators.

Methods: Human monocyte-derived macrophages were incubated with aldosterone alone, eplerenone alone, and the combination of aldosterone and eplerenone. The analyzed variables were nitric oxide and reactive oxygen species production, and the gene and protein expression of inducible nitric oxide synthase, arginase I, and mannose receptor.