Publications by authors named "Justus Nonhoff"
Article Synopsis
- Peripartum cardiomyopathy (PPCM) is a serious heart condition that affects women with no prior heart issues, and is linked to the 16 kDa-prolactin fragment that causes vascular damage and heart failure.
- In a study comparing healthy postpartum women to those with PPCM, PAI-1 levels were significantly higher in PPCM patients at baseline but decreased after six months, coinciding with an improvement in heart function (LVEF).
- The researchers found that increased miR-146a levels in PPCM patients correlated with elevated PAI-1 and was associated with higher NF-κB activation in endothelial cells, suggesting a role of PAI-1 in the disease's underlying mechanisms.
Aims: Peripartum cardiomyopathy (PPCM) is a systolic left ventricular dysfunction developing in the peripartum phase in previously healthy women. Relaxin-2 is a pregnancy hormone with potential beneficial effects in heart failure patients. We evaluated Relaxin-2 as a potential diagnostic marker and/or a therapeutic agent in PPCM.
View Article and Find Full Text PDFAims: Subsequent pregnancies (SSPs) in patients with peripartum cardiomyopathy (PPCM) have a high risk of heart failure relapse. We report on outcome of SSPs in PPCM patients in Germany, Scotland, and South Africa.
Methods And Results: Among 34 PPCM patients with a SSP, pregnancy ended prematurely in four patients while it was full-term in 30.
Pregnancy is associated with marked physiological changes challenging the cardiovascular system. Among the more severe pregnancy associated cardiovascular complications, peripartum cardiomyopathy (PPCM) is a potentially life-threatening heart disease emerging towards the end of pregnancy or in the first postpartal months in previously healthy women. A major challenge is to distinguish the peripartum discomforts in healthy women (fatigue, shortness of breath, and oedema) from the pathological symptoms of PPCM.
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