DWI lesions after intracranial aneurysm treatment with contour or WEB-does the device matter?

Objective: In this study, we report our experience with the occurrence of diffusion-weighted imaging (DWI) lesions following aneurysm treatment with Woven EndoBridge (WEB) device and Contour Neurovascular System in elective settings. We compared both techniques in a retrospective single-center analysis, to investigate whether there are significant differences in the incidence of microemboli depending on the device used.

Materials And Methods: Sixty-two cases treated with Contour were retrospectively compared with 84 WEB cases.

Contour device implantation for treatment of intracranial aneurysms in the basilar tip.

Introduction: Treatment of basilar apex aneurysms will remain challenging regarding the nobility of the parent vessel and their often wide-necked configuration. With endovascular techniques being the treatment approach of choice, novel intrasaccular flow-disruption devices constitute an endovascular embolization option. In this research, we report our experiences in embolizing basilar tip aneurysms with the novel Contour device.

Intra-cranial aneurysm treatment with contour or WEB - a single center comparison of intervention times and learning curves.

Background And Purpose: Treating aneurysms with intra-saccular flow disruption is a feasible alternative to coil-embolization. Besides the established WEB device, the novel Contour Neurovascular System has emerged as a potentially easier alternative regarding sizing and deployment. We report the learning curve experienced at our center from the first 48 patients treated with Contour and compared it with 48 consecutive WEB cases.

Interferon Regulatory Factor 4 controls T cell effector function and metabolism.

The transcription factor Interferon Regulatory Factor 4 (IRF4) is essential for T and T cell formation and controls peripheral CD8 T cell differentiation. We used Listeria monocytogenes infection to characterize the function of IRF4 in T responses. IRF4 mice generated only marginal numbers of listeria-specific T cells.