Publications by authors named "Justus Baumgarten"

Article Synopsis
  • The study aims to assess how video sequences (cine-loops) affect the agreement between different observers when using risk stratification systems (RSSs) to evaluate thyroid nodules (TNs).
  • Twelve experienced observers assessed twenty randomly selected TNs first using static ultrasound images and then again six months later using video sequences, with interobserver agreement measured using Fleiss' kappa (κ).
  • Results showed that interobserver agreement was generally better with static images than cine-loops, although experienced observers in RSSs had less variability in assessments using both methods.
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This study aims to assess the change in uptake to reference organs, including the liver, parotid and salivary glands after radioligand therapy (RLT) with [Lu]Lu-PSMA-617 in relation to pretreatment imaging metrics. Eighty-five patients with mCRPC underwent [Ga]Ga-PSMA-11 PET/CT imaging prior to (pre RLT PET) and after (post RLT PET) a median of 3 (IQR 2-6) RLT cycles with [Lu]Lu-PSMA-617. PSMA-positive tumor burden was stratified into 4 groups based on modified PROMISE criteria (oligofocal, multifocal, disseminated, diffuse).

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Key Clinical Message: In this case of struma ovarii a right-sided ovarian mass contained features of papillary thyroid cancer. Diagnostic iodine-123 revealed multiple foci of extraovarian spread, likely as a manifestation of concomitant peritoneal strumosis. Unilateral oophorectomy, partial peritonectomy, and adjuvant iodine-131 treatment were performed for successful curative treatment.

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Purpose: The currently used scheme for radioligand therapy (RLT) of patients with metastatic castration-resistant prostate cancer (mCRPC) consists of 4-6 cycles of 6.0-7.4 GBq [Lu]Lu-PSMA-617 each.

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Baseline uptake on prostate-specific membrane antigen (PSMA)-targeted imaging is a prerequisite for radioligand therapy (RLT) with [177Lu]Lu-PSMA-617. This study aims to quantify lesion-based response to RLT in relation to pretreatment standard molecular imaging metrics derived from [68Ga]Ga-PSMA-11 PET/CT. Sixty-one patients with mCRPC underwent [68Ga]Ga-PSMA-11 PET/CT imaging before and after a median of 4 (IQR 2−6) RLT cycles.

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Radiofrequency ablation is an effective tool to treat benign thyroid nodules up to about 100 ml. It is well tolerated and is - together with echopulse therapy - currently the most frequently used technique in Germany for the local therapy of benign thyroid nodules. Overall, a volume reduction of about 50 % to 70 % can be expected.

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Aim: Therapy success in patients with differentiated thyroid cancer (DTC) after thyroidectomy and radioiodine therapy (RIT) is proven by permanent decrease in human thyroglobulin (hTg) to <1 ng/mL. In this retrospective analysis hTg development before, during and after pregnancy were analyzed. Material and methods: A descriptive analysis of hTg courses in 47 women with 57 pregnancies under levothyroxine substitution was performed after treatment of DTC without evidence of residual or recurrent disease.

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Aim: The aim is to add a pragmatic contribution to the discussion of an algorithm to discharge patients treated with Lu-177-PSMA under the aspect of radiation protection. This also may be applied to therapies with other radioactive tracers in the future.

Material And Methods: 478 cycles of Lu-177-PSMA-617 (140 patients) were analyzed.

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Bone-seeking Radium-dichloride (Ra) is an established treatment prolonging survival and reducing morbidity in selected patients with metastatic castration-resistant prostate cancer (mCRPC) with skeletal involvement. Radioligand therapy with Lutetium-PSMA-617 (Lu-PSMA-617) has been increasingly implemented in patients with mCRPC failing conventional treatment options. In this study, the safety and efficacy of Lu-PSMA-617 in patients with progressive bone involvement under treatment with Ra was assessed.

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Article Synopsis
  • Mycobacterium genavense is a slow-growing bacterium primarily infecting immunocompromised individuals, particularly those with HIV, but also increasingly seen in non-HIV patients, resulting in difficult-to-treat infections.
  • A meta-analysis of 223 cases from 1992 to 2021 revealed gastrointestinal-related symptoms, such as abdominal pain and splenomegaly, as prominent clinical manifestations, with over 90% of patients receiving antimycobacterial treatment.
  • The study found high mortality rates associated with these infections, but indicated that regimens including macrolides might improve survival outcomes.
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Advanced stage metastatic prostate cancer with extensive bone marrow involvement is associated with a high risk of therapy-induced myelotoxicity and unfavorable outcomes. The role of salvage radioligand therapy (RLT) with Lu-PSMA-617 in this subset of patients remains to be further elucidated. Forty-five patients with progressive metastatic castration-resistant prostate cancer (mCRPC) and diffuse bone marrow involvement were treated with repeated cycles of RLT after having exhausted standard treatment options.

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Background: Myelosuppression is a potential dose-limiting factor in radioligand therapy (RLT). This study aims to investigate occurrence, severity and reversibility of hematotoxic adverse events in patients undergoing RLT with Lu-PSMA-617 for metastatic castration-resistant prostate cancer (mCRPC). The contribution of pretreatment risk factors and cumulative treatment activity is taken into account specifically.

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Aim: A supplementary diagnostic tool in the assessment of cold thyroid nodules is scintigraphic imaging withTc-MIBI. Aim of this study was to investigate the validity of this tool by determining the intra- and interobserver agreement in the assessment of cold thyroid nodules in Tc-MIBI scintigrams.

Methods: A retrospective study with 284 patients (16-85 years of age, 194 women, 90 men) was performed.

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