Publications by authors named "Justinija Steiner"
Article Synopsis
- Approximately one billion people are affected by metabolic-associated fatty liver disease (MAFLD), a chronic liver condition linked to metabolic issues like obesity and type 2 diabetes, which can lead to severe liver complications with minimal treatment options.
- The successful treatment for MAFLD requires a drug that reduces liver fat, inflammation, and fibrosis, with a focus on improving liver tissue health, but currently, only a few drugs like Saroglitazar have been approved in limited regions.
- Recent advancements show that research efforts are ramping up, with several promising drug candidates nearing approval, including Rezdiffra™, which received accelerated approval in the U.S. for treating MAFLD this year.
Aims: To determine the predictability of the MARKO questionnaire and/or its domains, individually or in combination with other markers and characteristics (age, gender, smoking history, lung function, 6-min walk test (6 MWT), exhaled breath temperature (EBT), and hsCRP for the incident chronic obstructive pulmonary disease (COPD) in subjects at risk over 2 years follow-up period).
Participants And Methods: Patients, smokers/ex-smokers with >20 pack-years, aged 40-65 years of both sexes were recruited and followed for 2 years. After recruitment and signing the informed consent at the GP, a detailed diagnostic workout was done by the pulmonologist; they completed three self-assessment questionnaires-MARKO, SGRQ and CAT, detailed history and physical, laboratory (CBC, hsCRP), lung function tests with bronchodilator and EBT.
Exhaled breath temperature (EBT) is a known biomarker of inflammation and airways blood flow. As opposed to previous studies, we were able to measure temperature of separate fractions of exhaled breath (fEBT) (those from the peripheral and central airways). The aim was to validate the fEBT measurement method to determine the reference values and the influence of endogenous and exogenous factors on fEBT in healthy subjects.
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