Publications by authors named "Justine V Devulder"
Chronic obstructive pulmonary disease (COPD) is associated with the acceleration of lung aging, and the accumulation of senescent cells in lung tissue. MicroRNA (miR)-34a induces senescence by suppressing the anti-aging molecule, sirtuin-1 (SIRT1). Senescent cells spread senescence to neighbouring and distant cells, favouring COPD progression and its comorbidities.
View Article and Find Full Text PDFUnveiling mechanisms of lung aging in COPD: A promising target for therapeutics development.
Chin Med J Pulm Crit Care Med
September 2024
Article Synopsis
- Chronic obstructive pulmonary disease (COPD) is a major lung disease leading to airflow limitations, associated with chronic bronchitis and emphysema, and it ranks as the third leading cause of death globally.
- The condition is more prevalent in individuals over 60, presenting features similar to accelerated lung aging, which involves deterioration in lung structure and function due to factors like oxidative stress and chronic inflammation.
- Recent studies are focusing on the role of senescent cells and their impact on lung aging and COPD, suggesting that targeting these aging mechanisms could pave the way for new treatments for COPD and related diseases.