Comprehensive analysis of chemical and enantiomeric stability of terpenes in Cannabis sativa L. flowers.

Objective: Cannabis sativa L. is renowned for its medicinal and recreational uses. With the increasing global legalization of C.

Simultaneous quantification of terpenes and cannabinoids by reversed-phase LC-APCI-MS/MS in Cannabis sativa L. samples combined with a subsequent chemometric analysis.

Cannabis sativa L. has been the most discussed medicinal plant in recent years. In particular, the dynamic shift from a formerly illicit and tightly controlled substance to a plant recognized for both medicinal and recreational purposes has brought C.

Exploring new dimensions: Single and multi-block analysis of essential oils using DBDI-MS and FT-IR for enhanced authenticity control.

Background: Essential oils (EOs) are complex mixtures of volatile hydrocarbons with a wide range of applications in the pharmaceutical, fragrance and food industry. The composition of EOs is highly variable and can affect their quality and pharmaceutical efficacy. Moreover, the high economic value of EOs, such as those obtained from Rosa damascena, make falsification and misclassification a lucrative business.

Determination of Major, Minor and Chiral Components as Quality and Authenticity Markers of Oil by GC-FID.

Rose oil is traditionally produced by the water distillation of and is of high economic value due to the low essential oil yield. It is therefore a common target for adulteration, which can cause harm to consumers. Current standards for authenticity control only consider the analysis of major components and overlook minor quality markers as well as the enantiomeric ratio of terpenes, which have proven useful in originality determination.

Easy and convenient millimole-scale synthesis of new, potential biomarkers for gamma-hydroxybutyric acid (GHB) intake: Feasible for analytical laboratories.

New biomarkers indicating the abuse of drugs and alcohol are still of major interest for clinical and forensic sciences. The endogenous neurotransmitter and approved drug, gamma-hydroxybutyric acid (GHB), is often illegally used for drug-facilitated crimes by spiking GHB into alcoholic beverages. Analytical detection windows of only 6 h in blood and 12 h in urine are often too short to provide reliable proof of GHB ingestion.

Towards Extending the Detection Window of Gamma-Hydroxybutyric Acid-An Untargeted Metabolomics Study in Serum and Urine Following Controlled Administration in Healthy Men.

In forensic toxicology, gamma-hydroxybutyrate (GHB) still represents one of the most challenging drugs of abuse in terms of analytical detection and interpretation. Given its rapid elimination, the detection window of GHB in common matrices is short (maximum 12 h in urine). Additionally, the differentiation from naturally occurring endogenous GHB, is challenging.

Identification of new urinary gamma-hydroxybutyric acid markers applying untargeted metabolomics analysis following placebo-controlled administration to humans.

Gamma-hydroxybutyrate (GHB) is a short-chain fatty acid that occurs naturally in the mammalian brain and is prescribed as a medication against narcolepsy or used as a drug of abuse. Particularly, its use as a knock-out drug in cases of drug-facilitated crimes is of major importance in forensic toxicology. Because of its rapid metabolism and resulting narrow detection windows (<12 hours in urine), detection of GHB remains challenging.