Publications by authors named "Justine Ledochowski"
Article Synopsis
- Motor impairments are common after childhood arterial ischemic stroke (C-AIS), affecting the understanding of how these impairments relate to intellectual abilities in children.
- A study of 34 children with C-AIS found that motor functioning in early recovery significantly correlates with various intellectual skills, including verbal and perceptual reasoning abilities.
- The results suggest that early motor deficits may influence intellectual development due to neuroplastic changes after injury, while motor functions assessed closer to testing reflect recovery and improvement potentially aided by interventions.
Background: Cognitive dysfunction (CD) is highly prevalent in systemic lupus erythematosus (SLE), yet the underlying mechanisms are poorly understood. Neuroimaging utilising advanced MRI metrics may yield mechanistic insights. We conducted a systematic review of neuroimaging studies to investigate the relationship between structural and diffusion MRI metrics and CD in SLE.
View Article and Find Full Text PDFNeurophysiological biomarkers of response inhibition and the familial risk for borderline personality disorder.
Prog Neuropsychopharmacol Biol Psychiatry
December 2021
Understanding of the biological factors that run in families affected with borderline personality disorder (BPD) is limited. The authors investigated the familial aggregation of neurophysiological biomarkers of response inhibition in the first-degree biological relatives of probands with BPD and associations with psychiatric diagnosis and impulsive traits. In the present study, psychiatric diagnoses and impulsive traits were measured in BPD probands (n = 86), psychiatrically affected and non-affected relatives (n = 60) and controls (n = 83).
View Article and Find Full Text PDFThis study examined the influence of executive functions on the association between callous-unemotional traits and severity and type of childhood disruptive behavior. Eighty one children aged 8-12 years and their parents participated in the study. We assessed children's callous-unemotional traits, executive functions, and two indices of disruptive behavior.
View Article and Find Full Text PDFArticle Synopsis
- * This study examined mental health outcomes in 75 children who had a basal ganglia stroke, specifically focusing on the impact of post-stroke dystonia on anxiety and depression symptoms.
- * Results showed that children with post-stroke dystonia had higher levels of anxiety and depression compared to those without dystonia, with motor and cognitive skills being largely independent from mental health outcomes.
Objective: Executive functions (EFs) have been assessed with performance-based measures and rating scales. Research has shown a lack of association between these two methods. One factor that might contribute to this difference is the structure provided on performance-based measures that is not provided on rating scales.
View Article and Find Full Text PDFBackground: Borderline personality disorder (BPD) is characterized by a heterogeneous clinical phenotype that emerges from interactions among genetic, biological, neurodevelopmental, and psychosocial factors. In the present family study, we evaluated the familial aggregation of key clinical, personality, and neurodevelopmental phenotypes in probands with BPD (n = 103), first-degree biological relatives (n = 74; 43% without a history of psychiatric disorder), and non-psychiatric controls (n = 99).
Methods: Participants were assessed on DSM-IV psychiatric diagnoses, symptom dimensions of emotion dysregulation and impulsivity, 'big five' personality traits, and neurodevelopmental characteristics, as part of a larger family study on neurocognitive, biological, and genetic markers in BPD.