Publications by authors named "Justine Adams"
Article Synopsis
- Young people with Duchenne muscular dystrophy (DMD) are at a higher risk for obesity, and this study aimed to explore a weight management program tailored for them and their families.
- The Supporting Nutrition and Optimizing Wellbeing Program (SNOW-P) was a 6-week intervention conducted via telehealth, focusing on diet and behavior, and involved feedback from caregivers to shape its structure.
- Results showed high participation and satisfaction, indicating feasibility and acceptability, but suggested improvements like the need for better online resources and a more accurate way to track weight and dietary habits.
Background: ATL1102 is a 2'MOE gapmer antisense oligonucleotide to the CD49d alpha subunit of VLA-4, inhibiting expression of CD49d on lymphocytes, reducing survival, activation and migration to sites of inflammation. Children with DMD have dystrophin deficient muscles susceptible to contraction induced injury, which triggers the immune system, exacerbating muscle damage. CD49d is a biomarker of disease severity in DMD, with increased numbers of high CD49d expressing T cells correlating with more severe and progressive weakess, despite corticosteroid treatment.
View Article and Find Full Text PDFIntroduction/aims: Boys with Duchenne muscular dystrophy (DMD) are at increased risk of fracture. This study investigated the incidence of fractures, factors contributing to risk of first fracture with emphasis on body mass index (BMI), and the impact of fractures on functional capacity in an Australian cohort of boys with DMD.
Methods: A retrospective cohort study included boys with DMD who attended a pediatric neuromuscular clinic from 2011 to 2018.
Article Synopsis
- Duchenne muscular dystrophy (DMD) is a serious genetic disorder affecting muscles, with a high percentage of affected young people experiencing obesity, which could worsen health outcomes.
- A study reviewed the clinical data of 158 young boys with DMD to assess how obesity influences their health milestones, finding a significant rise in obesity rates as they aged.
- The results showed that obesity in boys with DMD led to earlier diagnoses of obstructive sleep apnoea and fractures, emphasizing the need for early weight management interventions to mitigate these risks.
Article Synopsis
- The study focused on how the COVID-19 pandemic led to a shift from in-person appointments to telehealth (TH) in a neuromuscular clinic, exploring perceptions of TH from parents, children, and clinicians, and aiming to create a future care model.
- Data from a clinical audit and surveys revealed that while 62.8% of appointments were via TH in 2020, all groups preferred in-person interactions, though many parents recognized TH advantages, including reduced stress.
- The study concluded by creating a checklist for future hybrid care combining TH and in-person visits while emphasizing the need for more research on TH's health impacts in pediatric neuromuscular treatment.
Aim: Few studies have characterised the relationship between disease and gait function in children and young people with rare neuromuscular disorders (NMDs). This study aimed to describe the relationship between disease and gait in a large paediatric cohort from a neuromuscular outpatient clinic.
Methods: A prospective, cross-sectional study of gait in independently ambulant children and young people aged 4-21 years with a clinical or genetically confirmed NMD.