Publications by authors named "Justinas Pamedys"
Article Synopsis
- - Eccrine porocarcinoma is a complex skin tumor that can be difficult to diagnose, often requiring surgical excision for both diagnosis and treatment, with inconsistent data on surgical safety margins.
- - A systematic review analyzed 18 studies focused on surgical margins for porocarcinoma cases in the head and neck area, finding that most cases were in facial regions and on the scalp, with safety margins averaging 10.1 mm.
- - The review concluded that larger tumors typically require wider safety margins, but the lack of consistent safety margin reporting across studies highlights the need for further research and standardized guidelines.
Uveal melanoma (UM) is a rare malignant tumor that differs from cutaneous melanoma in terms of pathogenesis, clinical behavior, and treatment response. Despite treatment for the primary tumor, 50% of UM patients develop metastatic disease, with the liver being the most affected organ. Furthermore, UM responds poorly to chemotherapy and immune checkpoint inhibitors.
View Article and Find Full Text PDFBackground: Hepatic angiosarcoma is an uncommon, malignant, primary liver tumor, comprising 2% of liver cancers and accounting for < 1% of all sarcomas. Patients usually present with nonspecific symptoms, such as fatigue, weight loss, right upper quadrant pain, anemia, which leads to late diagnosis of an advanced stage tumor. The median life expectancy after the diagnosis of hepatic angiosarcoma is about 6 months, with only 3% of patients surviving more than 2 years.
View Article and Find Full Text PDFE3 ubiquitin ligases are of interest as drug targets due to their involvement in the regulation of the functions and interactions of several proteins. Various E3 ligase complexes are considered oncogenes or tumor suppressors associated with the development of melanoma. These proteins regulate the functions of various signaling pathways and proteins, such as p53 and Notch.
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