Ceftobiprole Medocaril: A New Fifth-Generation Cephalosporin.

Objective: The objective was to review the pharmacology, efficacy, and safety of intravenous ceftobiprole in the treatment of bloodstream infections, acute bacterial skin and skin structure infections (ABSSSIs), community-acquired pneumonia (CAP), and hospital-acquired pneumonia (HAP), or ventilator-associated pneumonia (VAP).

Data Sources: PubMed and ClinicalTrials.gov were searched using the following terms: ceftobiprole, ceftobiprole medocaril, ceftobiprole medocaril sodium, Zevtera, and BAL5788.

Multidrug Resistant in Clinical Settings: A Review of Resistance Mechanisms and Treatment Strategies.

is causing increasing concern among clinicians due to its high mortality and resistance rates. This bacterium is responsible for various infections, especially in hospital settings, affecting some of the most vulnerable patients. has developed resistance through multiple mechanisms, making treatment challenging.

Optimizing Heparin Quality Assurance Utilizing Electronic Data Abstraction.

Heparin is a high-risk medication with significant variability across patients. Systematic data analysis can help hospitals improve heparin management, ensuring safe and effective anticoagulation. An opportunity exists to create a more efficient data collection process, allowing hospitals to streamline quality assurance programs.

Acute Thoracic Myelopathy.

A 45-year-old man presented to an emergency department reporting back pain, bilateral lower extremity weakness with paresthesia, and 1 episode of bladder incontinence. Radiographs and magnetic resonance imaging of the thoracolumbar spine were negative for cauda equina syndrome and positive for central canal stenosis and cord signal change from T2 to T4. The emergency department referred him to his primary care provider, who referred him to physical therapy.

Genome-wide insertional mutagenesis of Arabidopsis thaliana.

Over 225,000 independent Agrobacterium transferred DNA (T-DNA) insertion events in the genome of the reference plant Arabidopsis thaliana have been created that represent near saturation of the gene space. The precise locations were determined for more than 88,000 T-DNA insertions, which resulted in the identification of mutations in more than 21,700 of the approximately 29,454 predicted Arabidopsis genes. Genome-wide analysis of the distribution of integration events revealed the existence of a large integration site bias at both the chromosome and gene levels.