Isolated limb perfusion (ILP) is a short term therapy used in conjunction with or without hyperthermia to deliver chemotherapeutic agents to localized areas, thus avoiding the severity of side effects caused by systemic administration. The most common treatment approach is hyperthermic isolated limb perfusion (HILP) with increased oxygenation of the chemotherapeutic perfusate for treatment of melanoma, soft tissue sarcoma, or synovial sarcoma. HILP traditionally involves open surgical dissection and direct cannulation.
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