Evaluating patients who present with pain complaints to a community hospital emergency department: Opioid prescription tracking software versus provider gestalt.

Objective: This study aimed to compare provider gestalt to assigned Narx score, a common prescription drug monitor-ing program (PDMP) component that gauges the patient's risk of misuse or abuse.

Design: This is a prospective, anonymous survey from advanced practice providers (APPs), emergency medicine resi-dents, and emergency medicine attendings.

Setting: Data from two emergency departments (EDs) within the OhioHealth network were included.

Inhibition of human γ-glutamyl transpeptidase: development of more potent, physiologically relevant, uncompetitive inhibitors.

GGT (γ-glutamyl transpeptidase) is an essential enzyme for maintaining cysteine homoeostasis, leukotriene synthesis, metabolism of glutathione conjugates and catabolism of extracellular glutathione. Overexpression of GGT has been implicated in many pathologies, and clinical inhibitors of GGT are under development for use in the treatment of asthma, cancer and other diseases. Inhibitors are generally characterized using synthetic GGT substrates.

Divergent effects of compounds on the hydrolysis and transpeptidation reactions of γ-glutamyl transpeptidase.

A novel class of inhibitors of the enzyme γ-glutamyl transpeptidase (GGT) were evaluated. The analog OU749 was shown previously to be an uncompetitive inhibitor of the GGT transpeptidation reaction. The data in this study show that it is an equally potent uncompetitive inhibitor of the hydrolysis reaction, the primary reaction catalyzed by GGT in vivo.