Publications by authors named "Justin Ng Tze Yang"
Article Synopsis
- L-PGDS is a transporter that binds heme and protects neuronal cells from hydrogen peroxide-induced cell death, acting as a pseudo-peroxidase with strong peroxidase activity.
- Studies show that the heme in the L-PGDS-heme complex is hexacoordinated with high-spin Fe(III), with hydrophobic interactions contributing to its stability.
- L-PGDS also plays a role as a chaperone for amyloid β in cerebrospinal fluid, but high bilirubin levels may hinder this function, although heme and its metabolites don’t significantly affect its neuroprotective properties.
