Publications by authors named "Justin N Corcoran"
Article Synopsis
- Overdoses of beta-adrenergic and calcium channel antagonists can lead to severe health issues, and treatment options include fluids, calcium salts, and high-dose insulin (HDI).
- A case report discusses a 51-year-old male who overdosed on a combination of amlodipine and metoprolol, requiring HDI and epinephrine to manage life-threatening symptoms, ultimately leading to his recovery.
- The study highlights that after stopping HDI, insulin levels remain elevated for an extended period, suggesting that patients may not need gradual reductions in insulin and often require dextrose supplementation.
Introduction: Calcium channel blocker (CCB) overdoses cause significant morbidity and mortality. Dihydropyridine CCBs cause peripheral vascular dilation and at high doses cardiac dysfunction. Amlodipine, a dihydropyridine, causes peripheral vasodilation from release of nitric oxide (NO) in addition to calcium channel blockade; NO scavenging is a potential treatment.
View Article and Find Full Text PDFIntroduction: Vasopressors are a commonly used treatment in beta-blocker poisoning despite evidence they may be ineffective or harmful. The primary objective of the present study is to use previously collected data from two prior studies (high-dose insulin (HDI) versus vasopressin + epinephrine and a placebo-controlled HDI study) to compare survival between vasopressin + epinephrine and placebo. Secondary outcomes included a comparison with HDI as well as comparisons with hemodynamic parameters, including mean arterial pressure (MAP), cardiac output (CO), heart rate (HR), and systemic vascular resistance (SVR).
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