Orthotopic Models Using New, Murine Lung Adenocarcinoma Cell Lines Simulate Human Non-Small Cell Lung Cancer Treated with Immunotherapy.

Understanding tumor-host immune interactions and the mechanisms of lung cancer response to immunotherapy is crucial. Current preclinical models used to study this often fall short of capturing the complexities of human lung cancer and lead to inconclusive results. To bridge the gap, we introduce two new murine monoclonal lung cancer cell lines for use in immunocompetent orthotopic models.

Severe Lymphoma-Associated Hemophagocytic Syndrome in a Young Woman.

Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening hyperinflammatory syndrome characterized by profound immune system activation. In adults, most cases of HLH are due to an underlying pathology- such as infection, malignancy, or autoimmune disease. It is a disease that can progress to rapid clinical deterioration and be difficult to diagnose.

Multisubstance-Using Probationers and the Odds of Arrest While in the Community.

Failed drug tests commonly lead to technical violations and revocation hearings for probationers. The current study extends these observations by examining whether multisubstance-using probationers also have increased odds of arrest in the community. This is important as multisubstance-using probationers may present unique public safety challenges to community corrections agencies and require intensive treatment resources and additional monitoring.

The Effects of Victimization and Fear of Crime on the Legal Socialization of Young Adolescents in São Paulo, Brazil.

It is important to understand how young adolescents come to view authorities during formative years. Experiencing, witnessing, and fearing victimization have been linked to the process of legal socialization and subsequent attitudes and behavior. In addition, procedural justice may influence adolescent perceptions of fairness of the authorities.

Neighborhood firearm victimization rates and social capital over time.

Distribution of firearm victimization is not equal within cities. Victimization can persistently concentrate in a small number of neighborhoods, while others experience very little violence. Theorists have pointed to one possible explanation as the ability of groups to control violence using social capital.