Inflammatory Alterations to Renal Lymphatic Endothelial Cell Gene Expression in Mouse Models of Hypertension.

Introduction: Hypertension (HTN) is a major cardiovascular disease that can cause and be worsened by renal damage and inflammation. We previously reported that renal lymphatic endothelial cells (LECs) increase in response to HTN and that augmenting lymphangiogenesis in the kidneys reduces blood pressure and renal pro-inflammatory immune cells in mice with various forms of HTN. Our aim was to evaluate the specific changes that renal LECs undergo in HTN.

Update on Immune Mechanisms in Hypertension.

The contribution of immune cells in the initiation and maintenance of hypertension is undeniable. Several studies have established the association between hypertension, inflammation, and immune cells from the innate and adaptive immune systems. Here, we provide an update to our 2017 American Journal of Hypertension review on the overview of the cellular immune responses involved in hypertension.

Changing the practice learning landscape.

Engagement in real life practice has long been acknowledged as the most effective way to learn a trade or profession and practice learning is consistently highlighted by nursing and midwifery placement students for its impact on both their professional and personal development. The paper examines the current complexities of practice learning that have emerged from educational reform and policy and debates the increased interest in the development of alternative approaches to practice learning in the UK.

Mental health and long-term conditions 2: Managing depression.

This second article in a two-part series on mental health and long-term conditions discusses the complex area of comorbid physical health and mental health problems. It focuses on depression--one of the most common mental illnesses--examining its prevalence and symptoms in people with long-term conditions, and how it can affect the ability to self-manage them. It also examines how nurses can support clients who experience depression as part of their long-term condition.

Mental health and long-term conditions.1: Physical health.

Poor diet, smoking, a lack of physical activity and excessive alcohol intake are just some of the factors that can contribute to a range of debilitating long-term conditions. Lifestyle risk factors can have a disproportionate impact on more vulnerable groups within society, such as people with mental health problems. In the first in a two-part series on mental health and long-term conditions, this article looks at the prevalence of physical illness among this service user group and how this affects mortality and morbidity.