Publications by authors named "Justin M Gray"
Article Synopsis
- Most tumor cells die through apoptosis due to immune responses and unfavorable environments, but the effects of dying cells on live tumor cells during metastasis are unclear.
- This study shows that dying cancer cells can actually promote the growth of surviving cancer cells through a process called Padi4-mediated nuclear expulsion, which creates a harmful DNA-protein complex.
- The study found that this complex activates receptors in nearby living tumor cells, leading to increased growth, and a similar nuclear expulsion pattern was observed in patients with breast, bladder, and lung cancer, correlating with worse outcomes.
nasal carriage is a common condition affecting both healthy and immunocompromised populations and provides a reservoir for dissemination of potentially infectious strains by casual contact. The factors regulating the onset and duration of nasal colonization are mostly unknown, and a human-relevant animal model is needed. Here, we screened 17 pig-tailed macaques () for carriage, and 14 of 17 animals tested positive in the nose at one or both screening sessions (8 weeks apart), while the other 3 animals were negative in the nose but positive in the pharynx at least once.
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