Gas transport mechanisms during high-frequency ventilation.

By virtue of applying small tidal volumes, high-frequency ventilation is advocated as a method of minimizing ventilator-induced lung injury. Lung protective benefits are established in infants, but not in other patient cohorts. Efforts to improve and extend the lung protection potential should consider how fundamental modes of gas transport can be exploited to minimize harmful tidal volumes while maintaining or improving ventilation.

Neonatal high-frequency oscillatory ventilation: where are we now?

High-frequency oscillatory ventilation (HFOV) is an established mode of respiratory support in the neonatal intensive care unit. Large clinical trial data is based on first intention use in preterm infants with acute respiratory distress syndrome. Clinical practice has evolved from this narrow population.

The impact of steady streaming and conditional turbulence on gas transport during high-frequency ventilation.

High-frequency ventilation is a type of mechanical ventilation therapy applied on patients with damaged or delicate lungs. However, the transport of oxygen down, and carbon dioxide up, the airway is governed by subtle transport processes which hitherto have been difficult to quantify. We investigate one of these mechanisms in detail, nonlinear mean streaming, and the impact of the onset of turbulence on this streaming, via direct numerical simulations of a model 1:2 bifurcating pipe.

Fourier amplitude distribution and intermittency in mechanically generated surface gravity waves.

We examine and discuss the spatial evolution of the statistical properties of mechanically generated surface gravity wave fields, initialized with unidirectional spectral energy distributions, uniformly distributed phases, and Rayleigh distributed amplitudes. We demonstrate that nonlinear interactions produce an energy cascade towards high frequency modes with a directional spread and trigger localized intermittent bursts. By analyzing the probability density function of Fourier mode amplitudes in the high frequency range of the wave energy spectrum, we show that a heavy-tailed distribution emerges with distance from the wave generator as a result of these intermittent bursts, departing from the originally imposed Rayleigh distribution, even under relatively weak nonlinear conditions.