Publications by authors named "Justin J Patten"
Article Synopsis
- Ebola virus disease (EVD) is a serious global health issue caused by six species of Orthoebolaviruses, with EBOV being the most significant in terms of public health.
- The virus primarily infects tissue macrophages, especially liver macrophages called Kupffer cells, contributing to high virus loads and causing a strong immune response.
- Research using primary and immortalized murine Kupffer cells showed that while interferon-gamma (IFN-γ) can temporarily reduce EBOV infection, the secreted immune responses were not sufficient to completely block the virus, highlighting the need for new antiviral therapies targeting macrophages.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), previously known as 2019 novel coronavirus (2019-nCoV), has spread rapidly across the globe, creating an unparalleled global health burden and spurring a deepening economic crisis. As of July 7th, 2020, almost seven months into the outbreak, there are no approved vaccines and few treatments available. Developing drugs that target multiple points in the viral life cycle could serve as a strategy to tackle the current as well as future coronavirus pandemics.
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