Publications by authors named "Justin Hoffmann"
Background: Macrolide-based treatment has been associated with survival benefit in patients hospitalized with community-acquired pneumonia (CAP). However, the influence of macrolide therapy in all patients hospitalized with pneumonia, including healthcare-associated pneumonia (HCAP), is unclear.
Methods: Analysis of a retrospective single-center cohort.
Background: ß-Lactam antibiotics demonstrate time-dependent killing. Prolonged infusion of these agents is commonly performed to optimize the time the unbound concentration of an antibiotic remains greater than the minimum inhibitory concentration and decrease costs, despite limited evidence suggesting improved clinical results.
Objective: To determine whether prolonged infusion of ß-lactam antibiotics improves outcomes in critically ill patients with suspected gram-negative infection.
Objective: To identify the determinants of hospital mortality among patients with septic shock receiving appropriate initial antibiotic treatment.
Design: A retrospective cohort study of hospitalized patients with blood culture positive septic shock (January 2002-December 2007).
Setting: Barnes-Jewish Hospital, a 1,250-bed urban teaching hospital.
Purpose: The purpose of this study was to determine the depth of penetration from mechanical chondroplasty and metabolic consequences of this procedure on the remaining articular cartilage.
Methods: Mechanical chondroplasty was performed in vitro on a portion of fresh grade I or II articular cartilage from 8 human knee arthroplasty specimens. Treated and control (untreated) explants (approximately 30 mg) were cut from the cartilage.