Publications by authors named "Justin H Kim"
Background: Radiofrequency ablation (RFA) is one of the treatment options for lung nodules. However, the need for exact delivery of the rigid metal electrode into the center of the target mass often leads to complications or suboptimal results. To overcome these limitations, a concept of conforming electrodes using a flexible material has been tested in this study.
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- The study investigates the impact of the intestinal immune system, particularly IgA immune cells, on insulin resistance linked to obesity from a high-fat diet (HFD).
- It reveals that HFD reduces IgA immune cells and their secretory form, which are essential for maintaining healthy glucose metabolism.
- Additionally, manipulation of IgA levels can influence inflammation, gut permeability, and microbiome composition, suggesting that targeting intestinal IgA could improve strategies for managing obesity-related metabolic disorders.
Obesity-related inflammation of metabolic tissues, including visceral adipose tissue (VAT) and liver, are key factors in the development of insulin resistance (IR), though many of the contributing mechanisms remain unclear. We show that nucleic-acid-targeting pathways downstream of extracellular trap (ET) formation, unmethylated CpG DNA, or ribonucleic acids drive inflammation in IR. High-fat diet (HFD)-fed mice show increased release of ETs in VAT, decreased systemic clearance of ETs, and increased autoantibodies against conserved nuclear antigens.
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