Publications by authors named "Justin Deschamps"
Neurofibromatosis type 1 (NF1) is a common autosomal dominant disorder. The role of angiogenesis and VEGF pathway in the pathogenesis of neurofibromas and malignant peripheral nerve sheath tumors (MPNSTs) remains poorly understood. We assessed the expression of VEGF and VEGFR family members in cohorts of plexiform neurofibromas (pNF), MPNSTs and MPNST cell lines at transcript [pNF, n = 49; MPNST, n = 34] and protein levels [pNF, n = 21; MPNST, n = 9].
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- Mycosis fungoides (MF) and primary cutaneous CD30-positive T-cell lymphoproliferative disorders (CD30LPD) are common skin lymphomas, and the study aimed to investigate T-cell antigens and PD-1 expression across a large sample of these conditions.
- The research involved analyzing 160 samples from patients, finding that CD7 was the most frequently lost antigen, especially in MF and CD30LPD, while benign inflammatory dermatoses showed no significant T-cell antigen loss.
- The study recommends using CD7 alongside other antigen markers like CD3, CD4, and CD8 for diagnosing MF, and suggests employing double staining techniques for more complex cases.