Publications by authors named "Justin D Searcy"
Article Synopsis
- Researchers isolated cytotoxic compounds from the plant Bridelia ferruginea using a method called bioactivity-guided fractionation, identifying several known substances including deoxypodophyllotoxin and neoechinulin.
- The study extended previous research on podophyllotoxin by investigating structural modifications of 4-aza-podophyllotoxin to improve its effectiveness.
- Some modified compounds showed strong cancer cell growth inhibitory activity, with GI50 values as low as 0.1 to <0.03 μg/mL, while 4'-demethylated versions were significantly less effective.
