Publications by authors named "Justin D Arnold"
Article Synopsis
- A retrospective study analyzed 435 infants with anogenital infantile hemangiomas (IHs), revealing that 73% of the patients were girls.
- The study found that 6.4% of these infants had associated congenital anomalies, with ulceration rates significantly higher for segmental or partial segmental IHs (72%) compared to focal IHs (45%).
- Key findings highlighted the increased odds of ulceration based on specific IH characteristics and locations, contributing to better understanding of high-risk features for these types of hemangiomas.
Baricitinib as the first systemic treatment for severe alopecia areata.
Expert Rev Clin Immunol
June 2023
Introduction: Alopecia areata is a heterogenous, immune-mediated hair loss disorder that can affect any hair-bearing site on the body. Despite being one of the most prevalent autoimmune skin diseases, treatments have historically been limited to off-label medications that have demonstrated limited efficacy, especially in more severe forms of disease. Thus, there has long been an unmet need for rigorously studied therapeutics in alopecia areata.
View Article and Find Full Text PDFThis cross-sectional study examines the characteristics of dermatology physician assistants in the US from 2013 to 2018.
View Article and Find Full Text PDFImportance: Hidradenitis suppurativa (HS) in pediatric patients has been understudied. Increased awareness and recognition of HS prevalence in children demand efforts to better understand this condition.
Objective: To describe the demographics, clinical features, treatment, associated comorbidities, and outcomes in a large cohort of pediatric patients with HS.
Article Synopsis
- The study investigates the unclear causes of vulvar lichen sclerosus (LS) and examines the potential role of skin and gut microbiota in its development.
- Researchers collected skin and stool samples from 13 prepubertal girls divided into three groups: those with LS, those with nonspecific vulvovaginitis, and healthy controls.
- Results showed significant differences in microbial communities, with girls with LS having higher levels of certain bacteria on their skin and in their gut compared to controls, suggesting a link between microbiota imbalances and vulvar LS that needs further exploration.
Importance: In the US, incidence of and mortality due to anal carcinoma are rising faster than for most other cancers. Identifying populations who have a higher risk of developing anal cancers is critical to target preventive interventions.
Objective: To assess the risk of developing anal carcinoma in adults living with HIV who have a history of anogenital warts.
Early intervention in cicatricial alopecias is critical to prevent permanent damage to the hair follicles. Previous literature, however, has suggested that individuals who are black are less likely to visit dermatologists than individuals who are white.1.
View Article and Find Full Text PDFBackground: Management of inpatient skin disease represents a unique subspecialty within dermatology.
Objective: To assess the national burden of inpatient dermatology in adults.
Methods: Using the 2014 National Inpatient Sample, we performed a retrospective cohort study of adults hospitalized for dermatologic conditions.
Background: Hospital readmissions represent a potential target for reducing unnecessary health care expenditures; however, readmissions following dermatology hospitalizations remain poorly characterized.
Objective: To assess the frequency and demographics of readmissions for skin disease.
Methods: We performed a retrospective cohort study of dermatology hospitalizations by using the 2014 Nationwide Readmissions Database.
Background/objectives: It is known that inpatient care accounts for a significant portion of health care expenditures, but the national burden of inpatient pediatric dermatology is poorly characterized. We sought to assess risk factors, conditions, and financial costs associated with pediatric hospitalizations for skin disease.
Methods: We performed a cross-sectional study of pediatric dermatology hospitalizations using the 2012 Kids' Inpatient Database, which samples 80% of non-birth-related pediatric admissions from 44 states to generate national estimates.
Article Synopsis
- The study aimed to assess the incidence of venous thromboembolism (VTE) among transgender women undergoing feminizing cross-sex hormone therapy (CSHT) in the U.S., where different hormone combinations are used compared to Europe.
- The research involved a retrospective chart review of 676 transgender women receiving oral estradiol over a period from 2008 to 2016, totaling 1,286 years of hormone treatment.
- The findings indicated a very low incidence of VTE, with only one case reported, resulting in an incidence rate of 7.8 events per 10,000 person-years.
Understanding how RNA binding proteins control the splicing code is fundamental to human biology and disease. Here, we present a comprehensive study to elucidate how heterogeneous nuclear ribonucleoparticle (hnRNP) proteins, among the most abundant RNA binding proteins, coordinate to regulate alternative pre-mRNA splicing (AS) in human cells. Using splicing-sensitive microarrays, crosslinking and immunoprecipitation coupled with high-throughput sequencing (CLIP-seq), and cDNA sequencing, we find that more than half of all AS events are regulated by multiple hnRNP proteins and that some combinations of hnRNP proteins exhibit significant synergy, whereas others act antagonistically.
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