Reduced hippocampal-cortical connectivity during memory suppression predicts the ability to forget unwanted memories.

The ability to suppress unwelcome memories is important for productivity and well-being. Successful memory suppression is associated with hippocampal deactivations and a concomitant disruption of this region's functionality. Much of the previous neuroimaging literature exploring such suppression-related hippocampal modulations has focused on the region's negative coupling with the prefrontal cortex.

Task compliance predicts suppression-induced forgetting in a large sample.

Suppression-induced forgetting (SIF) refers to a memory impairment resulting from repeated attempts to stop the retrieval of unwanted memory associates. SIF has become established in the literature through a growing number of reports built upon the Think/No-Think (TNT) paradigm. Not all individuals and not all reported experiments yield reliable forgetting, however.

Functional connectivity between right-lateralized ventrolateral prefrontal cortex and insula mediates reappraisal's link to memory control.

Background: Memory control (MC) ability is critical for people's mental and physical health. Previous research had conceptually demonstrated that MC ability has close relationship with reappraisal. However, experimental evidence supporting the relationship was limited.

Active Forgetting: Adaptation of Memory by Prefrontal Control.

Over the past century, psychologists have discussed whether forgetting might arise from active mechanisms that promote memory loss to achieve various functions, such as minimizing errors, facilitating learning, or regulating one's emotional state. The past decade has witnessed a great expansion in knowledge about the brain mechanisms underlying active forgetting in its varying forms. A core discovery concerns the role of the prefrontal cortex in exerting top-down control over mnemonic activity in the hippocampus and other brain structures, often via inhibitory control.

Does retrieving a memory insulate it against memory inhibition? A retroactive interference study.

Several recent studies suggest that an initial retrieval attempt imbues retrieved memories with special resilience against future interference and other forgetting mechanisms. Here we report two experiments examining whether memories established through initial retrieval remain subject to retrieval-induced forgetting. Using a version of a classical retroactive interference design, we trained participants on a list of A-B pairs via anticipation - constituting a form of retrieval practice.

Reductions in Retrieval Competition Predict the Benefit of Repeated Testing.

Repeated testing leads to improved long-term memory retention compared to repeated study, but the mechanism underlying this improvement remains controversial. In this work, we test the hypothesis that retrieval practice benefits subsequent recall by reducing competition from related memories. This hypothesis implies that the degree of reduction in competition between retrieval practice attempts should predict subsequent memory for practiced items.

What doesn't kill you makes you stronger: Psychological trauma and its relationship to enhanced memory control.

Control processes engaged in halting the automatic retrieval of unwanted memories have been shown to reduce the later recallability of the targets of suppression. Like other cognitive skills that benefit from practice, we hypothesized that memory control is similarly experience dependent, such that individuals with greater real-life experience at stopping retrieval would exhibit better inhibitory control over unwanted memories. Across two experiments, we found that college students reporting a greater history of trauma exhibited more suppression-induced forgetting of both negative and neutral memories than did those in a matched group who had reported experiencing little to no trauma.

Unintended side effects of a spotless mind: theory and practice.

Forgetting can be either a source of great frustration or one of great relief, depending on whether the memories in question are relevant to one's immediate goals. Adopting an appropriate strategy or memory mode can help achieve these goals. But do efforts to control memory engender unintended side effects? Presently, we expand on a theoretical perspective of memory control, wherein efforts to suppress episodic encoding or retrieval result in the systemic downregulation of the hippocampal memory system.

A neural signature of contextually mediated intentional forgetting.

The mental context in which we experience an event plays a fundamental role in how we organize our memories of an event (e.g. in relation to other events) and, in turn, how we retrieve those memories later.

Inducing amnesia through systemic suppression.

Hippocampal damage profoundly disrupts the ability to store new memories of life events. Amnesic windows might also occur in healthy people due to disturbed hippocampal function arising during mental processes that systemically reduce hippocampal activity. Intentionally suppressing memory retrieval (retrieval stopping) reduces hippocampal activity via control mechanisms mediated by the lateral prefrontal cortex.

Adaptive top-down suppression of hippocampal activity and the purging of intrusive memories from consciousness.

When reminded of unwanted memories, people often attempt to suppress these experiences from awareness. Prior work indicates that control processes mediated by the dorsolateral prefrontal cortex (DLPFC) modulate hippocampal activity during such retrieval suppression. It remains unknown whether this modulation plays a role in purging an intrusive memory from consciousness.

Evidence against associative blocking as a cause of cue-independent retrieval-induced forgetting.

Selectively retrieving an item from long-term memory reduces the accessibility of competing traces, a phenomenon known as retrieval-induced forgetting (RIF). RIF exhibits cue independence, or the tendency for forgetting to generalize to novel test cues, suggesting an inhibitory basis for this phenomenon. An alternative view (Camp, Pecher, & Schmidt, 2007; Camp et al.

The sleeping brain's influence on verbal memory: boosting resistance to interference.

Memories evolve. After learning something new, the brain initiates a complex set of post-learning processing that facilitates recall (i.e.

Understanding words in context: the role of Broca's area in word comprehension.

What role does meaning selection play in word comprehension, and what neural systems support this selection process? Most words have multiple meanings and are therefore ambiguous. This is true of both homonymous words (words that have multiple unrelated meanings) and polysemous words (words that have multiple related meanings). The extant evidence indicates that meaning selection is an integral part of homonym comprehension.

Interfering with theories of sleep and memory: sleep, declarative memory, and associative interference.

Mounting behavioral evidence in humans supports the claim that sleep leads to improvements in recently acquired, nondeclarative memories. Examples include motor-sequence learning; visual-discrimination learning; and perceptual learning of a synthetic language. In contrast, there are limited human data supporting a benefit of sleep for declarative (hippocampus-mediated) memory in humans (for review, see).