Publications by authors named "Justin Bobo"
The ability to model physiological systems through 3D neural in-vitro systems may enable new treatments for various diseases while lowering the need for challenging animal and human testing. Creating such an environment, and even more impactful, one that mimics human brain tissue under mechanical stimulation, would be extremely useful to study a range of human-specific biological processes and conditions related to brain trauma. One approach is to use human cerebral organoids (hCOs) in-vitro models.
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- - The text discusses the development of tissue-on-a-chip systems that aim to replicate the biological functions of physiological systems, particularly focusing on neuron-based models.
- - A specific innovation highlighted is the 3D Nerve Integrated Tissue on a Chip (NITC) combined with a Mechanical Excitation Testbed (MET), which allows for the application of mechanical stimulation to simulate realistic physical environments.
- - This research utilizes PC12 cells to study their calcium response under mechanical stimulation, emphasizing the importance of 3D systems for neurological studies and their potential applications in personalized medical strategies and biomaterials.