Fetuin-A adsorption and stabilization of calcium carbonate nanoparticles in a simulated body fluid.

Fetuin-A is a serum glycoprotein identified as a calcification inhibitor, and a key player in bone formation and human metabolic processes. A study on binding mechanisms of Fetuin-A with calcium carbonate nanoparticles in a simulated body fluid (DMEM) environment is presented. Observed interactions between Fetuin-A and the CaCO nanoparticles reveal an initial adsorption process, followed by a stabilization stage, and then a solubilization period for the Fetuin-A/CaCO complex.