Publications by authors named "Justin Ansel Jarrell"
The mechanisms underlying development of ribonucleoprotein (RNP) autoantibodies are unclear. The U1-70K protein is the predominant target of RNP autoantibodies, and the RNA binding domain has been shown to be the immunodominant autoantigenic region of U1-70K, although the specific epitopes are not known. To precisely map U1-70K epitopes, we developed silicon-based peptide microarrays with >5700 features, corresponding to 843 unique peptides derived from the U1-70K protein.
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- Systemic sclerosis is a disease where the body’s immune system accidentally damages the skin and organs, and this study looked at how a medicine called abatacept affects it.
- The study involved giving patients either abatacept or a dummy treatment (placebo) for 24 weeks to see how much their skin condition improved.
- Results showed that more patients taking abatacept had significant improvements in their skin score compared to those taking the placebo, but the side effects were similar in both groups.
Antigen-specific CD4(+) T cells are implicated in the autoimmune disease systemic lupus erythematosus (SLE), but little is known about the peptide antigens that they recognize and their precise function in disease. We generated a series of MHC class II tetramers of I-E(k)-containing peptides from the spliceosomal protein U1-70 that specifically stain distinct CD4(+) T-cell populations in MRL/lpr mice. The T-cell populations recognize an epitope differing only by the presence or absence of a single phosphate residue at position serine(140).
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