Clinical outcome and component-specific antibody levels in egg allergic children after lightened oral immunotherapy.

Objective: To evaluate the clinical outcome of lightened version of egg oral immunotherapy (OIT) and to analyze egg allergen component-specific antibody levels during short up-dosing with egg white powder and maintenance by egg in daily diet.

Patients And Methods: Eighteen egg-allergic children received egg powder with short up--dosing and they maintained tolerance using egg in daily diet. Seventeen egg-allergic children served as a control group.

Allergic contact dermatitis caused by glucose sensors in type 1 diabetes patients.

Background: Allergic contact dermatitis caused by glucose sensors has become an increasing problem. Contact allergies to isobornyl acrylate, colophonium, ethyl cyanoacrylate and N,N-dimethylacrylamide have been reported. However, there is a paucity of information regarding the prevalence of sensor-related dermatitis and detailed patient histories.

Patch testing and sensitization to multiple drugs.

Background: Adverse drug reactions pose an increasing diagnostic challenge in hospitals and in outpatient clinics. When consecutive or repeated allergic drug eruptions are suspected, patch testing is a useful diagnostic tool for determining the causative drugs.

Objectives: The aim of the study was to identify patient cases with multiple delayed-type drug sensitizations by using patch testing.

Non-occupational contact sensitization to epoxy resin of bisphenol A among general dermatology patients.

Background: Sensitization to epoxy resins often results from occupational exposure in various fields of construction and industry. Non-occupational sensitization sources and environments have remained overlooked.

Objectives: To analyse non-occupational and occupational contact sensitization to epoxy resin of bisphenol A among general dermatology patients.

The relevance of chlorhexidine contact allergy.

Background: Chlorhexidine is used for disinfection of skin and mucosae in medicine and dentistry. Prolonged exposure may lead to contact sensitization and allergic contact dermatitis or stomatitis.

Objectives: The purpose of this study was to analyse the sources of chlorhexidine exposure and sensitization, and to obtain data on the prevalence of sensitization and chlorhexidine-related contact allergy.

Contact sensitization to methylisothiazolinone in Finland--a multicentre study.

Background: Antimicrobials constitute the second most common cause of contact allergy to cosmetics. Methylisothiazolinone (MI), previously always used together with methylchloroisothiazolinone (MCI), has recently been approved in the EU for use on its own in cosmetics and also various industrial products. MCI has been classified as an extreme-strong and MI as a strong-moderate sensitizer.

Sensitization to thiourea derivatives among Finnish patients with suspected contact dermatitis.

Background: Thiourea derivatives in rubber products may induce contact sensitization and allergic contact dermatitis. Sensitization is most often from neoprene rubber, but the multitude of possible sensitizing products has remained poorly characterized.

Objective: The aim of this study was to collect information on the occurrence of thiourea-related contact allergy and to show novel sources of sensitization.

Allergy to carmine red (E120) is not dependent on concurrent mite allergy.

Background: Positive skin prick test (SPT) reactions to carmine red (E120) have been reported to occur concurrently with reactions to mites. The relationships between positive SPT reactions to carmine, carmine allergy and concurrent mite reactions are unknown. The aim of this study was to analyse the prevalence of carmine sensitization and its clinical importance among patients with suspected allergy to food additives.

Sources of sensitization, cross-reactions, and occupational sensitization to topical anaesthetics among general dermatology patients.

Background: Contact sensitization to local anaesthetics is often from topical medicaments. Occupational sensitization to topical anaesthetics may occur in certain occupations.

Objectives: The aim of the study was to analyse the occurrence of contact sensitization to topical anaesthetics in general dermatology patients.

Positive patch test reactions to gentamicin show sensitization to aminoglycosides from topical therapies, bone cements, and from systemic medication.

Background: A history of prolonged use of topical antimicrobials is common among patients with positive patch test reactions to gentamicin and to aminoglycosides.

Objectives: The aim of this study was to show sources of gentamicin sensitization in patients with positive patch test reactions to gentamicin.

Patients And Methods: About 7814 patients were patch tested with a baseline patch test series and 620 of them were further tested with gentamicin.

Contact sensitization to 4,4'-diaminodiphenylmethane and to isocyanates among general dermatology patients.

Background: Diisocyanates and 4,4'-diaminodiphenylmethane (MDA) are industrial sensitizers. Occupational asthma is a risk among workers exposed to diisocyanates. Exposure may also lead to contact sensitization and allergic contact dermatitis.

Quantification of human Aiolos splice variants by real-time PCR.

Aiolos is a transcriptional regulator of B cell development and belongs to the Ikaros family of chromatin remodelling transcription factors. All the members of Ikaros family produce multiple isoforms via alternative mRNA splicing. Altered expression of Ikaros isoforms has been found in patients with acute lymphoblastic leukemia but it is not studied whether the altered expression of Aiolos isoforms also has a role in the development of leukemias or lymphomas.