Cannabinoid Receptor Type 1 in Parkinson's Disease: A Positron Emission Tomography Study with [ F]FMPEP-d.

Background: The endocannabinoid system is a widespread neuromodulatory system affecting several biological functions and processes. High densities of type 1 cannabinoid (CB1) receptors and endocannabinoids are found in basal ganglia, which makes them an interesting target group for drug development in basal ganglia disorders such as Parkinson's disease (PD).

Objective: The aim of this study was to investigate CB1 receptors in PD with [ F]FMPEP-d positron emission tomography (PET) and the effect of dopaminergic medication on the [ F]FMPEP-d binding.