Transversal modes and Higgs bosons in electroweak vector-boson scattering at the LHC.

Processes where and bosons scatter into pairs of electroweak bosons , , and Higgs, are sensitive probes of new physics in the electroweak sector. We study simplified models that describe typical scenarios of new physics and parameterize the range of possible LHC results between the standard-model prediction and unitarity limits. Extending the study beyond purely longitudinal scattering, we investigate the role of transversally polarized gauge bosons.

Precise predictions for same-sign W-boson scattering at the LHC.

Vector-boson scattering processes are of great importance for the current run-II and future runs of the Large Hadron Collider. The presence of triple and quartic gauge couplings in the process gives access to the gauge sector of the Standard Model (SM) and possible new-physics contributions there. To test any new-physics hypothesis, sound knowledge of the SM contributions is necessary, with a precision which at least matches the experimental uncertainties of existing and forthcoming measurements.

Next-to-leading order QCD corrections to the production of two bottom-antibottom pairs at the LHC.

We report the results of a computation of the full next-to-leading order QCD corrections to the production of two bb pairs at the LHC. This calculation at the parton level provides predictions for well separated b jets. The results show that the next-to-leading order corrections lead to an enhancement of the cross section for the central scale choice by roughly 50% with respect to the leading order result.

STRAP is a strong predictive marker of adjuvant chemotherapy benefit in colorectal cancer.

Background: Molecular predictors for the effectiveness of adjuvant chemotherapy in colorectal cancer are of considerable clinical interest. To this aim, we analyzed the serine threonine receptor-associated protein (STRAP), an inhibitor of TGF-beta signaling, with regard to prognosis and prediction of adjuvant 5-FU chemotherapy benefit.

Methods: The gene copy status of STRAP was determined using quantitative real-time polymerase chain reaction in 166 colorectal tumor biopsies, which had been collected from a randomized multicenter trial of 5-fluorouracil (5-FU)/mitomycin C (MMC) adjuvant chemotherapy of the Swiss Group for Clinical Cancer Research (SAKK).

Amplification of SKI is a prognostic marker in early colorectal cancer.

Background: Improved risk stratification of early colorectal cancer might help to better select patients for adjuvant treatment. Alterations in the transforming growth factor-beta (TGF-beta) pathway have frequently been found in colorectal cancer, but their impact on prognosis remains controversial. We therefore analyzed two transcriptional corepressors of the TGF-beta signaling pathway with respect to prognosis and prediction of chemotherapy benefit in early colorectal cancer.

DCR3 locus is a predictive marker for 5-fluorouracil-based adjuvant chemotherapy in colorectal cancer.

Adjuvant chemotherapy reduces the incidence of distant metastasis and increases survival of patients with colorectal cancer. However, predictive markers are needed to define subsets of patients with stage II and III disease that may benefit from adjuvant treatment. A secreted member of the TNF receptor superfamily, the decoy receptor 3 (DcR3), was reported to be amplified in colorectal cancer as a negative regulator of Fas-mediated apoptosis.